用途 靶点 体外研究 体内研究 脱氧半乳糖野生霉素 盐酸盐 试剂级价格
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脱氧半乳糖野生霉素 盐酸盐

脱氧半乳糖野生霉素 盐酸盐,75172-81-5,结构式
脱氧半乳糖野生霉素 盐酸盐
  • CAS号:75172-81-5
  • 英文名:Deoxygalactonojirimycin Hydrochloride
  • 中文名:脱氧半乳糖野生霉素 盐酸盐
  • CBNumber:CB5252941
  • 分子式:C6H13NO4.ClH
  • 分子量:199.63
  • MOL File:75172-81-5.mol
脱氧半乳糖野生霉素 盐酸盐化学性质
  • 熔点 :260
  • 储存条件 :2-8°C
  • 溶解度 :Methanol (Slightly), Water (Slightly)
  • 形态 :White crystalline solid
  • 颜色 :White to Brown
安全信息
  • 危险品标志 :Xi
  • 危险类别码 :36/37/38
  • 安全说明 :26-36
  • WGK Germany :3
  • Hazard Note :Irritant
  • 海关编码 :29333990

脱氧半乳糖野生霉素 盐酸盐性质、用途与生产工艺

  • 用途

    脱氧半乳糖野生霉素盐酸盐是一种有效和竞争性的α-galactosidase A抑制剂,对人α-Gal A的 IC50值为0.04 μM。

  • 靶点

    IC50: 0.04 μM (human α-Gal A); Ki: 0.04 μM (human α-Gal A)

  • 体外研究

    Both IC 50 and K i values of Migalastat (GR181413A) hydrochloride toward human lysosomal a-Gal A are 0.04 μM.

  • 体内研究

    Fabry disease is an X-linked recessive disorder caused by the deficient activity of α-galactosidase A. α-Gal A activity in heart, kidney, spleen, and liver is increased dose- and time-dependently in transgenic mice that express human mutant alpha-Gal A with Migalastat (GR181413A) hydrochloride treatment. The half-life of DGJ is less than 1 day in all major issues and that of the enzyme synthesized during the DGJ treatment period is approximately 4 days. Oral administration of Migalastat (GR181413A) hydrochloride reduces tissue GL-3 in fabry transgenic mice, and in urine and kidneys of some FD patients. Oral administration of Migalastat (GR181413A) hydrochloride to transgenic mice reduces elevated lyso-Gb3 levels up to 64%, 59%, and 81% in kidney, heart, and skin, respectively, generally equal to or greater than observed for GL-3.

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脱氧半乳糖野生霉素 盐酸盐 试剂级价格
  • 更新日期:2024/11/08
  • 产品编号:HY-14929A
  • 产品名称:Migalastat hydrochloride
  • CAS编号:
  • 包装:1 mg
  • 价格:386元
  • 更新日期:2024/11/08
  • 产品编号:HY-14929A
  • 产品名称:脱氧半乳糖野生霉素 盐酸盐 Migalastat hydrochloride
  • CAS编号:75172-81-5
  • 包装:5mg
  • 价格:750元
脱氧半乳糖野生霉素 盐酸盐生产厂家
  • 公司名称:GlycoFineChem
  • 联系电话:--
  • 电子邮件:glycofinechem@viclink.co.nz
  • 国家:新西兰
  • 产品数:43
  • 优势度:30
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