CONOPHYLLINE
- CAS号:142741-24-0
- 英文名:Cophylline
- 中文名:CONOPHYLLINE
- CBNumber:CB52519637
- 分子式:C44H50N4O10
- 分子量:794.9
- MOL File:142741-24-0.mol
- 密度 :1.53±0.1 g/cm3(Predicted)
- 储存条件 :Store at -20°C
- 酸度系数(pKa) :10.73±0.70(Predicted)
CONOPHYLLINE性质、用途与生产工艺
- 生物活性 Conophylline 是一种从热带植物 Ervatamia microphylla 中提取的长春花生物碱。Conophylline 是胰腺细胞分化的诱导剂。Conophylline 能抑制 HSC，诱导其凋亡。
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体外研究
Conophylline (100 ng/ml; 48 hours) reproduces differentiationinducing activity but not apoptosis-inducing activity of activin.
Conophylline (100 ng/ml; 72 hours) exhibits the differentiation-inducing activity in AR42J cells and converts these cells to endocrine cells.
Conophylline increases the expression of neurogenin-3 by activating p38 mitogen-activated protein kinase to induce differentiation of AR42J cells.
Conophylline reduces the expression of α-SMA and collagen-1 in rat HSC and Lx-2 cells.
Conophylline inhibits DNA synthesis induced by serum.
Conophylline also promots activation of caspase-3 and induces apoptosis in Lx-2 Cells.
Apoptosis Analysis
Cell Line: Lx-2 Cells Concentration: 12 hours Incubation Time: 0.1 μg/ml Result: Induced apoptosis Western Blot Analysis
Cell Line: Lx-2 cells Concentration: 0.1 μg/ml Incubation Time: 15 minutes, 30 minutes, 60 minutes, 120 minutes Result: Increased phospho-JNK. -
体内研究
Conophylline (0.9 mg/kg; p.o.; daily; for 12 weeks) attenuates formation of the liver fibrosis induced by TAA in vivo.
Animal Model: Sprague-Dawley rats (70-80 g) Dosage: 0.9 mg/kg Administration: Oral administration; daily; for 12 weeks Result: Attenuated formation of the liver fibrosis induced by TAA.
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