ChemicalBook CAS数据库列表 ZAMIFENACIN
ZAMIFENACIN
- CAS号:127308-82-1
- 英文名:ZAMIFENACIN
- 中文名:ZAMIFENACIN
- CBNumber:CB52446434
- 分子式:C27H29NO3
- 分子量:415.52
- MOL File:127308-82-1.mol
ZAMIFENACIN化学性质
- 储存条件 :Store at -20°C
- 形态 :Solid
- 颜色 :Off-white to light yellow
ZAMIFENACIN性质、用途与生产工艺
- 生物活性 Zamifenacin (UK-76654) 是一种有效的肠道选择性毒蕈碱 M3 受体拮抗剂。Zamifenacin 可显着降低肠易激综合症的结肠蠕动。
-
靶点
Muscarinic M3 receptor
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体内研究
Zamifenacin exhibits moderate oral bioavailability (mouse 26%, rat 64%, dog 100%) and C max (mouse 92, rat 905, dog 416 ng/mL) following oral administration (mouse 13.2, rat 20 and, dog 5 mg/kg).
Zamifenacin exhibits terminal elimination half-lives (mouse 2.1, rat 6.0 and, dog 1.1 h) due to high plasma clearance (68, 35, and 39 mL/min/kg respectively) combined with large volumes of distribution (12.5, 19.0, and 3.5 L/kg respectively) following intravenous administration (mouse 5.3, rat 5.0 and, dog 1.0 mg/kg).Animal Model: Male CDl mice (mean weight 23 g) Dosage: 5.3 mg/kg for i.v.; 13.2 mg/kg for oral (Pharmacokinetic Analysis) Administration: Intravenous administration and oral administration Result: Oral bioavailability (26%), C max (92 ng/mL), T 1/2 (2.1 h). Animal Model: Male and female CD rats (mean weight 210 g) Dosage: 5.0 mg/kg for i.v.; 20 mg/kg for oral (Pharmacokinetic Analysis) Administration: Intravenous administration and oral administration Result: Oral bioavailability (64%), C max (905 ng/mL), T 1/2 (6.0 h). Animal Model: Male and two female beagle dogs (13-16 kg) Dosage: 1.0 mg/kg for i.v.; 5 mg/kg for oral (Pharmacokinetic Analysis) Administration: Intravenous administration and oral administration Result: Oral bioavailability (100%), C max (416 ng/mL), T 1/2 (1.1 h).
ZAMIFENACIN上下游产品信息
上游原料
下游产品
ZAMIFENACIN生产厂家
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：+1-781-999-5354 +1-00000000000
- 电子邮件：marketing@targetmol.com
- 国家：美国
- 产品数：32165
- 优势度：58
- 公司名称：Alchem Pharmtech,Inc.
- 联系电话：8485655694
- 电子邮件：sales@alchempharmtech.com
- 国家：美国
- 产品数：63687
- 优势度：58
- 公司名称：TargetMol Chemicals Inc.
- 联系电话： +8613564774135
- 电子邮件：zijue.cai@tsbiochem.com
- 国家：美国
- 产品数：19885
- 优势度：58
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
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