ZAMIFENACIN
中文名称:ZAMIFENACIN
英文名称:ZAMIFENACIN
CAS号:127308-82-1
分子式:C27H29NO3
分子量:415.52
EINECS号:
Mol文件:127308-82-1.mol
ZAMIFENACIN 用途与合成方法
Zamifenacin (UK-76654) 是一种有效的肠道选择性毒蕈碱 M3 受体拮抗剂。Zamifenacin 可显着降低肠易激综合症的结肠蠕动。
Muscarinic M3 receptor
Zamifenacin exhibits moderate oral bioavailability (mouse 26%, rat 64%, dog 100%) and C
max
(mouse 92, rat 905, dog 416 ng/mL) following oral administration (mouse 13.2, rat 20 and, dog 5 mg/kg).
Zamifenacin exhibits terminal elimination half-lives (mouse 2.1, rat 6.0 and, dog 1.1 h) due to high plasma clearance (68, 35, and 39 mL/min/kg respectively) combined with large volumes of distribution (12.5, 19.0, and 3.5 L/kg respectively) following intravenous administration (mouse 5.3, rat 5.0 and, dog 1.0 mg/kg).
| Animal Model: | Male CDl mice (mean weight 23 g) |
| Dosage: | 5.3 mg/kg for i.v.; 13.2 mg/kg for oral (Pharmacokinetic Analysis) |
| Administration: | Intravenous administration and oral administration |
| Result: | Oral bioavailability (26%), C max (92 ng/mL), T 1/2 (2.1 h). |
| Animal Model: | Male and female CD rats (mean weight 210 g) |
| Dosage: | 5.0 mg/kg for i.v.; 20 mg/kg for oral (Pharmacokinetic Analysis) |
| Administration: | Intravenous administration and oral administration |
| Result: | Oral bioavailability (64%), C max (905 ng/mL), T 1/2 (6.0 h). |
| Animal Model: | Male and two female beagle dogs (13-16 kg) |
| Dosage: | 1.0 mg/kg for i.v.; 5 mg/kg for oral (Pharmacokinetic Analysis) |
| Administration: | Intravenous administration and oral administration |
| Result: | Oral bioavailability (100%), C max (416 ng/mL), T 1/2 (1.1 h). |
ZAMIFENACIN供应商 更多
ChemeGen 中国
联系电话： 18818260767
产品介绍：
英文名称：Zamifenacin
CAS：127308-82-1
纯度：98%
包装信息：10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注：品牌：ChemeGen
天津普西唐生物医药科技有限公司
联系电话：010-60605840 15801484223
产品介绍：
英文名称：Zamifenacin
CAS：127308-82-1
纯度：98%
包装信息：5mg;10mg;25mg;50mg;100mg
TargetMol中国（陶术生物）
联系电话： 4008200310
产品介绍：
中文名称：化合物 T17283
英文名称：Zamifenacin;Zamifenacin
CAS：127308-82-1
纯度：98%
包装信息：100 mg;25 mg;50 mg
