ChemicalBook CAS数据库列表 (E)-位变异烟碱
(E)-位变异烟碱
- CAS号:15585-43-0
- 英文名:rivanicline
- 中文名:(E)-位变异烟碱
- CBNumber:CB51508612
- 分子式:C10H14N2
- 分子量:162.23156
- MOL File:15585-43-0.mol
(E)-位变异烟碱化学性质
- 沸点 :99-101°C/0.4mm Hg
- 密度 :0.980
- 闪点 :130℃
- 储存条件 :2-8°C(protect from light)
- 溶解度 :Soluble in DMSO
- 形态 :Powder
- 酸度系数(pKa) :10.03±0.10(Predicted)
- 稳定性 :Hygroscopic
(E)-位变异烟碱性质、用途与生产工艺
- 生物活性 Rivanicline (RJR-2403; (E)-Metanicotine) 是神经元烟碱受体(neuronal nicotinic receptor) 的抑制剂，对 α4β2 亚型有高度选择性，Ki 为 26 nM，比对 α7 受体的抑制性高超过1000倍。
- 用途 An alkaloid found in the leaves of Duboisia Hopwoodii, and a constitutent of tobacco smoke. Also used a potential drug for the treatment of senile dementia of the Alzheimer鈥檚 type and currently being investigated as a nicotinic agonist with CNS selectivity. Metanicotine may have clinical potential due to its high selectivity for CNS nicotinic acetylcholine receptor subtypes relative to periphera l ganglionic and muscle-type nicotinic acetylcholine receptors.
(E)-位变异烟碱上下游产品信息
上游原料
下游产品
(E)-位变异烟碱生产厂家
- 公司名称：TORONTO
- 联系电话：--
- 电子邮件：info@trc-canada.com
- 国家：加拿大
- 产品数：6038
- 优势度：71
