蛋白酶体抑制剂

蛋白酶体抑制剂化学性质

熔点 :233-235°C dec.
沸点 :714.9±60.0 °C(Predicted)
密度 :1.367±0.06 g/cm3(Predicted)
储存条件 :-20°C
溶解度 :Soluble in DMSO (up to 20 mg/ml), in Water (up to 10 mg/ml), or in Ethanol (up to 1 mg/ml).
形态 :powder
酸度系数(pKa) :3.11±0.10(Predicted)
颜色 :White to off-white
水溶解性 :Soluble to 10 mM in water
稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. Solutions in water are not stable and must be used with one working day. Aqueous solutions should not be stored.

安全信息

蛋白酶体抑制剂性质、用途与生产工艺

生物活性 Lactacystin 是一种抗生素，链霉菌属的代谢物，是一种有效的选择性蛋白酶体 (proteasome) 抑制剂，对 20S 蛋白酶体的 IC50 为 4.8 μM。Lactacystin 还抑制溶酶体酶组织蛋白酶 A。Lactacystin 抑制细胞生长并诱导神经突增生。
靶点

IC50: 4.8 μM (proteasome)

体内研究

Lactacystin (microinjection; 2 µg) induces a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice.

Animal Model:	Male C57Bl/6RccHsd mice with 8-9 weeks (young) and 12-14 months (adult) old
Dosage:	2 µg
Administration:	Microinjection
Result:	Induced a Parkinson’s disease-like motor phenotype 5-7 days after injection in young and adult mice.

蛋白酶体抑制剂上下游产品信息

上游原料

下游产品

蛋白酶体抑制剂试剂级价格

蛋白酶体抑制剂生产厂家

133343-34-7, 蛋白酶体抑制剂相关搜索: