吡罗达韦

作用生物活性靶点体外研究吡罗达韦试剂级价格

吡罗达韦

CAS号:124436-59-5
英文名:pirodavir
中文名:吡罗达韦
CBNumber:CB51073567
分子式:C21H27N3O3
分子量:369.46
MOL File:124436-59-5.mol

吡罗达韦化学性质

熔点 :124-125℃
储存条件 :Sealed in dry,Store in freezer, under -20°C
溶解度 :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
形态 :Solid
颜色 :Off-White to Pale Beige

安全信息

海关编码 :2933.99.7500

吡罗达韦性质、用途与生产工艺

作用吡罗达韦是由Janssen研究基金会发现的。这个化合物有抑制许多鼻病毒血清型复制的显著活性，在体外的抗病毒能力强，在0.1微克/毫升或更低浓度其可以抑制大约80%的鼻病毒血清型。吡罗达韦作用在鼻病毒的疏水性口袋，通过阻止病毒粘附和抑制病毒脱壳来发挥抗病毒作用。
生物活性 Pirodavir 是一种有效的小核糖核酸病毒抑制剂，高效作用于 A 和 B 型鼻病毒(rhinovirus)。Pirodavir 非常有效作用于病毒产量减少试验，IC90 为 2.3 nM。
靶点

Rhinovirus
体外研究

Pirodavir is a potent, broad-spectrum picornavirus inhibitor. Pirodavir inhibits 80 of the 100 human rhinovirus (HRV) strains tested at a concentration of 64 ng/mL. In that same study, Pirodavir is also effective in inhibiting 16 enteroviruses, with a mean 80% inhibitory concentration (IC ₈₀ ) of 1,300 ng/mL. Pirodavir inhibits enterovirus 71 replication with an IC ₅₀ of 5,420 nM and an IC ₉₀ of >13,350 nM. Pirodavir inhibits 56 rhinovirus laboratory strains and three of the clinical isolates tested. Pirodavir inhibits 59% of the serotypes and isolates with IC ₅₀ s of <100 nM. Pirodavir concentrations of 16 and 4μg/mL reduces cell growth by 66% (s.e.m. 0.75) and 28% (s.e.m. 0.25), respectively. Lower concentrations (1μg/mL) of Pirodavir are not inhibitory for cell growth. The 50% cytotoxic concentration of pirodavir for logarithmic cell growth at 37°C is 7μg/mL. Under the conditions of the antiviral assay (confluent HeLa cells at 33°C), the 50% cytotoxic concentration is >50μg/mL.