生物活性 靶点 体外研究 左色满卡林 试剂级价格
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左色满卡林

左色满卡林,94535-50-9,结构式
左色满卡林
  • CAS号:94535-50-9
  • 英文名:LEVCROMAKALIM
  • 中文名:左色满卡林
  • CBNumber:CB5104507
  • 分子式:C16H18N2O3
  • 分子量:286.33
  • MOL File:94535-50-9.mol
左色满卡林化学性质
  • 熔点 :242-244°
  • 比旋光度 :D26 -52.2° (c = 1 in chloroform)
  • 沸点 :482.3±45.0 °C(Predicted)
  • 密度 :1.31±0.1 g/cm3(Predicted)
  • 储存条件 :Store at RT
  • 溶解度 :DMSO: ≤10 mM, soluble
  • 酸度系数(pKa) :13.18±0.60(Predicted)
  • 形态 :solid
  • 颜色 :White to off-white
安全信息
  • 安全说明 :22-24/25
  • WGK Germany :3
  • RTECS号 :DJ2177500

左色满卡林性质、用途与生产工艺

  • 生物活性 Levcromakalim ((-)-Cromakalim) 是 ATP 敏感性的 K+ 通道 (KATP) 激活剂。
  • 靶点

    K + channel

  • 体外研究

    Levcromakalim ((-)-Cromakalim) inhibits spontaneous contractions completely in a glibenclamide-sensitive manner. LevCromakalim (5 µM) inhibits spontaneous contractions, which are recovered by glibenclamide. Levcromakalim (1, 5 and 10 µM) inhibits phasic contractions to 34±21.1%, 20.1±20.0% and 0% of the control (n=5, respectively; P<0.05). Glibenclamide reverses the inhibition of spontaneous isometric contractions caused by LevCromakalim (5 µM) to 84±1.5% of the control (n=5; P<0.05). Levcromakalim (20 and 100 µM) also inhibits oxytocin (OXT) (10 nM)-induced phasic contractions to 34±21.4% and 14±12.6% of the control (n=6 and 4, respectively; P<0.05). Glibenclamide reverses the inhibition of spontaneous isometric contractions by LevCromakalim (100 µM) to 79±3.5% of the control (n=4; P<0.05). Tonic contraction by OXT is also suppressed by Cromakalim in a glibenclamide-sensitive manner.The function of the K ATP channels is examined with the specific channel opener LevCromakalim (Cromakalim). LevCromakalim induces dose-dependent relaxation in both the young and old mesenteric artery (MAs); and there is no difference in relaxation with age. However, the relaxation is markedly reduced in response to the high-salt (HS) diet in the old MAs (P<0.05). Maximum dilations to Levcromakalim (10 -4 M) are 97 ± 3% in the young MAs versus 98 ± 1% in the young salt arteries, while dilations are 99±0.7% in the old MAs when compared with 85 ± 5% in the old salt arteries (P<0.05).

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左色满卡林 试剂级价格
  • 更新日期:2024/11/08
  • 产品编号:HY-14255
  • 产品名称:左色满卡林 Levcromakalim
  • CAS编号:94535-50-9
  • 包装:2 mg
  • 价格:800元
  • 更新日期:2024/11/08
  • 产品编号:HY-14255
  • 产品名称:左色满卡林 Levcromakalim
  • CAS编号:94535-50-9
  • 包装:5mg
  • 价格:1200元
左色满卡林生产厂家
  • 公司名称:MedChemexpress LLC
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  • 联系电话:888-539-0666
  • 电子邮件:info@emmx.com
  • 国家:美国
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  • 公司名称:TopScience Biochemical
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  • 国家:中国香港
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  • 电子邮件:sales@ubiochem.com
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