盐酸环丙沙星(一水物)

生物活性体外研究体内研究盐酸环丙沙星(一水物) 试剂级价格

盐酸环丙沙星(一水物)

CAS号:86393-32-0
英文名:Ciprofloxacin hydrochloride hydrate
中文名:盐酸环丙沙星(一水物)
CBNumber:CB4740508
分子式:C17H21ClFN3O4
分子量:385.82
MOL File:86393-32-0.mol

盐酸环丙沙星(一水物)化学性质

熔点 :318-320 °C
RTECS号 :VB1993800
储存条件 :Inert atmosphere,Store in freezer, under -20°C
溶解度 :Soluble in water, slightly soluble in methanol, very slightly soluble in anhydrous ethanol, practically insoluble in acetone, in ethyl acetate and in methylene chloride.
形态 :Solid
颜色 :White to Light yellow
PH值 :pH (25g/l, 25℃) 3.0～4.5
水溶解性 :Soluble in water (35mg/ml).
Merck :14,2314
InChIKey :DIOIOSKKIYDRIQ-UHFFFAOYSA-N
CAS 数据库 :86393-32-0(CAS DataBase Reference)

安全信息

WGK Germany :3
危险等级 :IRRITANT
海关编码 :2933595960

盐酸环丙沙星(一水物)性质、用途与生产工艺

生物活性 Ciprofloxacin Hydrochloride (Ciloxan, Ceprimax, Oftacilox) 是ciprofloxacin的盐酸盐形式，ciprofloxacin是一种抗生素，用于治疗一些细菌感染疾病。
体外研究

Ciprofloxacin (hydrochloride monohydrate) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Ciprofloxacin (hydrochloride monohydrate) (CIP) shows potent activity against Y. pestis with MIC ₉₀ of 0.03 μg/mL.
体内研究

Ciprofloxacin (hydrochloride monohydrate) (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin (hydrochloride monohydrate) (≥10 μg/L) is ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae. In a murine model of pneumonic plague, Ciprofloxacin (hydrochloride monohydrate) (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin (hydrochloride monohydrate). Intraperitoneal Ciprofloxacin (hydrochloride monohydrate) reduces the lung bacterial load compare to controls treated with intraperitoneal PBS.
化学性质白色或微黄色结晶粉末。易溶于水，微溶于甲醇，难溶于乙醇。
用途该品为广谱抗生素。通过抑制细菌DNA旋转酶，使DNA合成和复制受阻而导致细菌死亡。对大肠杆菌、克雷白杆菌和其他肠杆菌属有较强抗菌活性；对绿脓杆菌、金黄色葡萄球菌和肺炎链球菌的抗菌作用优于诺氟沙星和培氟沙星。用于敏感菌所致的中耳炎、外耳道炎和鼓膜炎等。偶有中耳痛及瘙痒感。
用途该品味广谱抗生素。通过抑制细菌DNA旋转酶，使DNA合成和复制受阻而导致细菌死亡。对大肠杆菌，克雷白杆菌和其他肠杆菌属有较强抗菌活性、对绿脓杆菌、金黄色葡萄球菌和肺炎链球菌的抗菌作用优于诺氟沙星和培氟沙星。用于敏感菌所致的中耳炎，外耳道炎和骨膜炎等。偶有中耳痛及瘙痒感。
用途广谱抗菌类药，适用于重混合感染，主要用于慢性呼吸道、大肠杆菌药、传染性鼻炎、禽霍乱、禽伤寒等