生物活性 体外研究 美托拉宗 试剂级价格
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美托拉宗

美托拉宗,17560-51-9,结构式
美托拉宗
  • CAS号:17560-51-9
  • 英文名:Metolazone
  • 中文名:美托拉宗
  • CBNumber:CB4725936
  • 分子式:C16H16ClN3O3S
  • 分子量:365.83
  • MOL File:17560-51-9.mol
美托拉宗化学性质
  • 熔点 :252-254°C
  • 沸点 :613.6±65.0 °C(Predicted)
  • 密度 :1.2895 (rough estimate)
  • 折射率 :1.6100 (estimate)
  • 储存条件 :2-8°C
  • 溶解度 :DMSO: >5mg/mL
  • 酸度系数(pKa) :pKa 9.7 (Uncertain)
  • 形态 :solid
  • 颜色 :white
  • 水溶解性 :60.3mg/L(25 ºC)
  • 稳定性 :Stable for 2 years as supplied. Solutions in DMSO may be stored desiccated at -20°C for up to 2 months.
  • InChIKey :AQCHWTWZEMGIFD-UHFFFAOYSA-N
  • CAS 数据库 :17560-51-9(CAS DataBase Reference)
  • NIST化学物质信息 :Metolazone(17560-51-9)
安全信息
  • WGK Germany :2
  • RTECS号 :VA1700000
  • 海关编码 :2935904000
  • 毒害物质数据 :17560-51-9(Hazardous Substances Data)
  • 毒性 :LD50 in mice (mg/kg): >5000 orally; >1500 i.p. (Shetty, 1967)

美托拉宗 MSDS


Metolazone

美托拉宗性质、用途与生产工艺

  • 生物活性 Metolazone (SR 720-22)是一种利尿剂,主要用于治疗充血性心脏衰竭和高血压。
  • 体外研究

    Metolazone (SR-720-22) is a thiazide-like diuretic marketed under the brand names Zytanix from Zydus Cadila, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess fluid accumulation in heart failure. Metolazone is sometimes used together with loop diuretics such as furosemide or bumetanide, but these highly effective combinations can lead to dehydration and electrolyte abnormalities. Metolazone and the other thiazide diuretics inhibit the function of the sodium-chloride symporter, preventing sodium and chloride, and therefore water too, from leaving the lumen to enter the tubule cell. As a result, water remains in the lumen and is excreted as urine, instead of being reabsorbed into the bloodstream. Since most of the sodium in the lumen has already been reabsorbed by the time the filtrate reaches the distal convoluted tubule, thiazide diuretics have limited effects on water balance and on electrolyte levels. Nevertheless, they can be associated with low sodium levels, volume depletion, and low blood pressure, among other adverse effects.

  • 用途  利尿药。
美托拉宗上下游产品信息
上游原料
下游产品
美托拉宗 试剂级价格
  • 更新日期:2024/11/08
  • 产品编号:HY-B0209
  • 产品名称:美托拉宗 Metolazone
  • CAS编号:17560-51-9
  • 包装:50mg
  • 价格:600元
  • 更新日期:2024/11/08
  • 产品编号:HY-B0209
  • 产品名称:美托拉宗 Metolazone
  • CAS编号:17560-51-9
  • 包装:10mM * 1mLin DMSO
  • 价格:660元
美托拉宗生产厂家
  • 公司名称:北京华威锐科化工有限公司
  • 联系电话:0757-86329057 18934348241
  • 电子邮件:sales4.gd@hwrkchemical.com
  • 国家:中国
  • 产品数:14063
  • 优势度:55
  • 公司名称:嘉兴市艾森化工有限公司
  • 联系电话:0573-85285100 18627885956
  • 电子邮件:isenchem@163.com
  • 国家:中国
  • 产品数:9513
  • 优势度:66
  • 公司名称:Pure Chemistry Scientific Inc.
  • 联系电话:001-857-928-2050 or 1-888-588-9418
  • 电子邮件:sales@chemreagents.com
  • 国家:美国
  • 产品数:10186
  • 优势度:62
  • 公司名称:北京华美互利生物化工
  • 联系电话:010-56205725
  • 电子邮件:waley188@sohu.com
  • 国家:中国
  • 产品数:12335
  • 优势度:58
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