17560-51-9
基本信息
美托拉宗
美托拉腙
甲醋唑胺
DIULO
METENIX
METOLAZONE
MYKROX
OLDREN
SR-720-22
1,2,3,4-tetrahydro-7-chloro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamid
2-methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
6-quinazolinesulfonamide,7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylpheny
6-quinazolinesulfonamide,7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-toly
7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolines
7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesul
7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamid
7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-tolyl-6-quinazolinesulfonamide
fonamide
l)-4-oxo-
metalozone
microx
s720-22
物理化学性质
| 熔点 | 252-254°C |
| 沸点 | 613.6±65.0 °C(Predicted) |
| 密度 | 1.2895 (rough estimate) |
| 折射率 | 1.6100 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：>5mg/mL |
| 酸度系数(pKa) | pKa 9.7 (Uncertain) |
| 形态 | 固体 |
| 颜色 | 白色 |
| 水溶解性 | 60.3mg/L(25 ºC) |
| 稳定性 | 自购买之日起 2 年内保持稳定。 DMSO 中的溶液可在 -20°C 下干燥保存长达 2 个月。 |
| 主要应用 | pharmaceutical (small molecule) |
| InChI | 1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23) |
| InChIKey | AQCHWTWZEMGIFD-UHFFFAOYSA-N |
| SMILES | CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(N)(=O)=O |
| CAS 数据库 | 17560-51-9(CAS DataBase Reference) |
| NIST化学物质信息 | Metolazone(17560-51-9) |
安全数据
| 危险性符号(GHS) |  GHS07 |
| 警示词 | 警告 |
| 危险性描述 | H315-H319-H335 |
| 防范说明 | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| WGK Germany | 2 |
| RTECS号 | VA1700000 |
| 海关编码 | 2935904000 |
| 存储类别 | 11 - Combustible Solids |
| 毒害物质数据 | 17560-51-9(Hazardous Substances Data) |
| 毒性 | LD50 in mice (mg/kg): >5000 orally; >1500 i.p. (Shetty, 1967) |
应用领域
知名试剂公司产品信息
美托拉宗价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/09/15 | HY-B0209R | 美托拉宗 Metolazone (Standard) | 17560-51-9 | 5 mg | 280元 |
| 2026/09/15 | HY-B0209R | 美托拉宗 Metolazone (Standard) | 17560-51-9 | 10 mg | 442元 |
| 2026/09/15 | HY-B0209R | 美托拉宗 Metolazone (Standard) | 17560-51-9 | 25 mg | 885元 |
常见问题列表
Metolazone (SR-720-22) is a thiazide-like diuretic marketed under the brand names Zytanix from Zydus Cadila, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess fluid accumulation in heart failure. Metolazone is sometimes used together with loop diuretics such as furosemide or bumetanide, but these highly effective combinations can lead to dehydration and electrolyte abnormalities. Metolazone and the other thiazide diuretics inhibit the function of the sodium-chloride symporter, preventing sodium and chloride, and therefore water too, from leaving the lumen to enter the tubule cell. As a result, water remains in the lumen and is excreted as urine, instead of being reabsorbed into the bloodstream. Since most of the sodium in the lumen has already been reabsorbed by the time the filtrate reaches the distal convoluted tubule, thiazide diuretics have limited effects on water balance and on electrolyte levels. Nevertheless, they can be associated with low sodium levels, volume depletion, and low blood pressure, among other adverse effects.