ChemicalBook CAS数据库列表 3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)
3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)
- CAS号:945260-14-0
- 英文名:3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)
- 中文名:3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)
- CBNumber:CB45864995
- 分子式:C35H30N4O5
- 分子量:586.64
- MOL File:Mol file
3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)化学性质
- 密度 :1.53±0.1 g/cm3(Predicted)
- 酸度系数(pKa) :12.23±0.70(Predicted)
3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)性质、用途与生产工艺
- 生物活性 (S)-3-Hydroxy Midostaurin ((S)-CGP52421) 是一种有效的激酶抑制剂，对 VEGFR-2，TRK-A，FLT3 等 13 种激酶的 IC50 值为 <400 nM。(S)-3-Hydroxy Midostaurin 是 Midostaurin (PKC412; HY-10230) 通过肝 CYP3A4 酶代谢的次要代谢产物。(S)-3-Hydroxy Midostaurin 具有潜在的用于急性髓细胞性白血病 (AML) 的潜力。
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体外研究
(S)-3-Hydroxy Midostaurin ((S)-CGP52421; compound 4) has IC 50 values in the range of 200-400 nM against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme.
The epimeric mixture of metabolites ((R)-3-Hydroxy Midostaurin + (S)-3-Hydroxy Midostaurin) substantially inhibits the proliferation of only the Tel-PDGFRβ (GI 50 =63 nM), KIT D816V (GI 50 =320 nM), and FLT3-ITD (GI 50 =650 nM) BaF3 cell lines, while the wild-type cells are relatively insensitive.
3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)上下游产品信息
上游原料
下游产品
3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1)生产厂家
- 公司名称：TargetMol Chemicals Inc.
- 联系电话：+1-781-999-5354 +1-00000000000
- 电子邮件：marketing@targetmol.com
- 国家：美国
- 产品数：32165
- 优势度：58
- 公司名称：MedChemExpress
- 联系电话：--
- 电子邮件：sales@medchemexpress.com
- 国家：美国
- 产品数：6398
- 优势度：58
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