1-十二烷基咪唑

生物活性体外研究体内研究 1-十二烷基咪唑试剂级价格

1-十二烷基咪唑

CAS号:4303-67-7
英文名:1-DODECYLIMIDAZOLE
中文名:1-十二烷基咪唑
CBNumber:CB4495420
分子式:C15H28N2
分子量:236.4
MOL File:4303-67-7.mol

1-十二烷基咪唑化学性质

熔点 :69.5-70.5 °C(Solv: ethyl acetate (141-78-6))
沸点 :146 °C (0.5 mmHg)
密度 :0.9624 (rough estimate)
蒸气压 :0.009Pa at 20℃
折射率 :1.5312 (estimate)
储存条件 :Sealed in dry,2-8°C
溶解度 :Chloroform (Slightly), Methanol (Slightly)
酸度系数(pKa) :7.08±0.10(Predicted)
形态 :Liquid
颜色 :Clear yellow
LogP :3.56-5.5 at pH5-9
表面张力 :45mN/m at 20mg/L and 20℃
EPA化学物质信息 :1H-Imidazole, 1-dodecyl- (4303-67-7)

安全信息

危险品标志 :Xi
危险类别码 :36/37/38
安全说明 :37/39-26
海关编码 :29332990

1-十二烷基咪唑性质、用途与生产工艺

生物活性 1-Dodecylimidazole (N-Dodecylimidazole) 是一种溶酶体活性洗涤剂和细胞毒性剂。1-Dodecylimidazole 通过其在溶酶体中的酸依赖性积累、溶酶体膜的破坏和半胱氨酸蛋白酶释放到细胞质中而导致细胞死亡。1-Dodecylimidazole 具有降胆固醇和广谱抗真菌活性。
体外研究

N-dodecylimidazole, an acid activated detergent with a pKa of 6.3, has been shown to be cytotoxic to cells in culture. N-dodecylimidazole displayed extracellular pH (pHe)-dependent cytotoxicity against EMT-6 and MGH U1 cells. cell killing was dose dependent and was 100-fold greater at pHe 6.0 than pHe 7.0.

体内研究

The hypocholesterolaemic activity of 1-dodecylimidazole results in part from the inhibition of cholesterol biosynthesis at the level of 2,3-oxidosqualene sterol cyclase.
1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) has lower serum cholesterol concentrations than control rats.

Animal Model:	Male rats
Dosage:	150 mg/kg body wt
Administration:	By stomach tube; daily for 10 days
Result:	Had significantly lower serum cholesterol concentrations than untreated animals.