ChemicalBook CAS数据库列表 1-十二烷基咪唑
1-十二烷基咪唑
- CAS号:4303-67-7
- 英文名:1-DODECYLIMIDAZOLE
- 中文名:1-十二烷基咪唑
- CBNumber:CB4495420
- 分子式:C15H28N2
- 分子量:236.4
- MOL File:4303-67-7.mol
1-十二烷基咪唑化学性质
- 熔点 :69.5-70.5 °C(Solv: ethyl acetate (141-78-6))
- 沸点 :146 °C (0.5 mmHg)
- 密度 :0.9624 (rough estimate)
- 蒸气压 :0.009Pa at 20℃
- 折射率 :1.5312 (estimate)
- 储存条件 :Sealed in dry,2-8°C
- 溶解度 :Chloroform (Slightly), Methanol (Slightly)
- 酸度系数(pKa) :7.08±0.10(Predicted)
- 形态 :Liquid
- 颜色 :Clear yellow
- LogP :3.56-5.5 at pH5-9
- 表面张力 :45mN/m at 20mg/L and 20℃
- EPA化学物质信息 :1H-Imidazole, 1-dodecyl- (4303-67-7)
安全信息
1-十二烷基咪唑性质、用途与生产工艺
- 生物活性 1-Dodecylimidazole (N-Dodecylimidazole) 是一种溶酶体活性洗涤剂和细胞毒性剂。1-Dodecylimidazole 通过其在溶酶体中的酸依赖性积累、溶酶体膜的破坏和半胱氨酸蛋白酶释放到细胞质中而导致细胞死亡。1-Dodecylimidazole 具有降胆固醇和广谱抗真菌活性。
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体外研究
N-dodecylimidazole, an acid activated detergent with a pKa of 6.3, has been shown to be cytotoxic to cells in culture. N-dodecylimidazole displayed extracellular pH (pHe)-dependent cytotoxicity against EMT-6 and MGH U1 cells. cell killing was dose dependent and was 100-fold greater at pHe 6.0 than pHe 7.0.
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体内研究
The hypocholesterolaemic activity of 1-dodecylimidazole results in part from the inhibition of cholesterol biosynthesis at the level of 2,3-oxidosqualene sterol cyclase.
1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) has lower serum cholesterol concentrations than control rats.Animal Model: Male rats Dosage: 150 mg/kg body wt Administration: By stomach tube; daily for 10 days Result: Had significantly lower serum cholesterol concentrations than untreated animals.
1-十二烷基咪唑上下游产品信息
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下游产品
1-十二烷基咪唑 试剂级价格
- 更新日期：2024/11/08
- 产品编号：38170
- 产品名称：1-十二烷基咪唑 1-dodecylimidazole, 97%, Thermo Scientific Chemicals
- CAS编号：4303-67-7
- 包装：1g
- 价格：1115元
- 更新日期：2024/11/08
- 产品编号：XW02430367704
- 产品名称：1-十二烷基咪唑
- CAS编号：4303-67-7
- 包装：25G
- 价格：1543元
1-十二烷基咪唑生产厂家
- 公司名称：MDP ChemControl Ltd.
- 联系电话：--
- 电子邮件：chemcontrol@nextra.sk
- 国家：斯洛伐克
- 产品数：6700
- 优势度：60
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