ChemicalBook CAS数据库列表 N-乙酰基-S-法呢基-L-半胱氨酸
N-乙酰基-S-法呢基-L-半胱氨酸
- CAS号:135304-07-3
- 英文名:AFC
- 中文名:N-乙酰基-S-法呢基-L-半胱氨酸
- CBNumber:CB4379892
- 分子式:C20H33NO3S
- 分子量:367.55
- MOL File:135304-07-3.mol
N-乙酰基-S-法呢基-L-半胱氨酸化学性质
- 沸点 :566.1±50.0 °C(Predicted)
- 密度 :1.038±0.06 g/cm3(Predicted)
- 储存条件 :-15°C
- 溶解度 :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
- 形态 :Pale yellow oil.
- 酸度系数(pKa) :3.31±0.10(Predicted)
- 颜色 :Yellow
- 稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- LogP :5.860 (est)
安全信息
- 危险等级 :IRRITANT
N-乙酰基-S-法呢基-L-半胱氨酸性质、用途与生产工艺
- 生物活性 Arazine (N-Acetyl-S-farnesyl-L-cysteine) 是 G 蛋白和 G 蛋白偶联受体 (G protein and G-protein coupled receptor) 信号传导的细胞渗透性调节剂。Arazine 可与异戊烯化的 G 蛋白或其受体位点竞争，成为异戊二烯基半胱氨酸甲基转移酶的底物。
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体外研究
Arazine (2 hours) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell. Arazine (10–100 μM;8 hours) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell.
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体内研究
Arazine (AFC) (2,000 μg/20 μl; applied on ear) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with a 50% effective dose (ED 50 ) of 55±12 μg/20 μl.
Animal Model: TPA-induced ear acute inflammation in mouse Dosage: 2000 μg/20 μl Administration: 2000 μg/20 μl; Applied on ear Result: Inhibited ear edema, as measured by ear weight.
N-乙酰基-S-法呢基-L-半胱氨酸上下游产品信息
上游原料
下游产品
N-乙酰基-S-法呢基-L-半胱氨酸生产厂家
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6100
- 优势度：58
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