羟基氯喹EP杂质D-d5二盐酸

羟基氯喹EP杂质D-d5二盐酸化学性质

熔点 :94-97?C
沸点 :173-175 °C(Press: 0.05 Torr)
密度 :1.138±0.06 g/cm3(Predicted)
储存条件 :-20°C Freezer
溶解度 :Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly), Met
形态 :Solid
酸度系数(pKa) :10.62±0.19(Predicted)
颜色 :Pale Yellow to Dark Yellow

安全信息

羟基氯喹EP杂质D-d5二盐酸性质、用途与生产工艺

生物活性 Desethyl chloroquine 是 Chloroquine 的主要去乙基代谢产物。Chloroquine 是一种自噬和 toll-like receptors (TLRs) 的抑制剂。Desethyl chloroquine 具有抗疟原虫活性。
体外研究

P. falciparum
体内研究

Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame.

羟基氯喹EP杂质D-d5二盐酸上下游产品信息

上游原料

下游产品

羟基氯喹EP杂质D-d5二盐酸生产厂家

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