米福贝特
- CAS号:76541-72-5
- 英文名:SR 202
- 中文名:米福贝特
- CBNumber:CB4285085
- 分子式:C11H17ClO7P2
- 分子量:358.65
- MOL File:76541-72-5.mol
- 沸点 :436.6±45.0 °C(Predicted)
- 密度 :1.355±0.06 g/cm3(Predicted)
- 储存条件 :Inert atmosphere,Store in freezer, under -20°C
- 溶解度 :DMSO: 5 mg/mL
- 形态 :crystalline
- 颜色 :white
- 水溶解性 :Soluble to 100 mM in water
- 安全说明 :22-24/25
- WGK Germany :2
- RTECS号 :TB8817000
米福贝特性质、用途与生产工艺
- 生物活性 Mifobate (SR-202) 是一种有效且特异性的 PPARγ 拮抗剂，可选择性的抑制噻唑烷二酮 (TZD) 诱导的 PPARγ 转录活性 (IC50=140 μM)。Mifobate 不影响 PPARα，PPARβ 或 FXR 的基础或配体刺激的转录活性。Mifobate 具有抗肥胖和抗糖尿病作用。
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靶点
PPARγ
140 μM (IC 50 )
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体外研究
Mifobate (100-400 μM; pretreated with 24 hours) significantly inhibits BRL 49653- and hormone-induced adipocyte differentiation of 3T3-L1 cells in a dose-dependent manner after 6 days.
Mifobate is able to both interact specifically with PPARγ and inhibit its agonist-dependent interaction with the coactivator steroid receptor coactivator-1 (SRC-1). Mifobate (SR-202) inhibits TZD-stimulated recruitment of the coactivator steroid receptor coactivator-1. Mifobate blocks adipocyte differentiation induced either by thiazolidinediones or by the combination of dexamethasone, insulin, and 3-isobutyl-1-methylxanthine (IBMX). -
体内研究
Mifobate (400 mg/kg; Feed for 20 days) increases insulin sensitivity in ob/ob mice
Animal Model: Eight-week-old male ob/ob mice Dosage: 400 mg/kg Administration: Feed (food admixture maintained for 20 days) Result: Prevented the time-dependent increase in glucose concentrations.
- 更新日期：2024/11/08
- 产品编号：HY-100277
- 产品名称：米福贝特 Mifobate
- CAS编号：76541-72-5
- 包装：1mg
- 价格：880元
- 更新日期：2024/11/08
- 产品编号：HY-100277
- 产品名称：米福贝特 Mifobate
- CAS编号：76541-72-5
- 包装：5mg
- 价格：2500元
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
