米福贝特
米福贝特 性质
| 沸点 | 436.6±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.355±0.06 g/cm3(Predicted) |
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 在DMSO中的溶解度为5 毫克/毫升 |
| 形态 | 结晶 |
| 颜色 | 白色 |
| 水溶解性 | Soluble to 100 mM in water |
米福贝特 用途与合成方法
|
PPARγ 140 μM (IC 50 ) |
Mifobate (100-400 μM; pretreated with 24 hours) significantly inhibits BRL 49653- and hormone-induced adipocyte differentiation of 3T3-L1 cells in a dose-dependent manner after 6 days.
Mifobate is able to both interact specifically with PPARγ and inhibit its agonist-dependent interaction with the coactivator steroid receptor coactivator-1 (SRC-1). Mifobate (SR-202) inhibits TZD-stimulated recruitment of the coactivator steroid receptor coactivator-1. Mifobate blocks adipocyte differentiation induced either by thiazolidinediones or by the combination of dexamethasone, insulin, and 3-isobutyl-1-methylxanthine (IBMX).
Mifobate (400 mg/kg; Feed for 20 days) increases insulin sensitivity in ob/ob mice
| Animal Model: | Eight-week-old male ob/ob mice |
| Dosage: | 400 mg/kg |
| Administration: | Feed (food admixture maintained for 20 days) |
| Result: | Prevented the time-dependent increase in glucose concentrations. |
米福贝特 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-100277 | 米福贝特 | 76541-72-5 | 1mg | 880 |
| 2024-11-08 | HY-100277 | 米福贝特 | 76541-72-5 | 5mg | 2500 |
