WNT AGONIST 1 (CID11210285 盐酸盐)
- CAS号:853220-52-7
- 英文名:Wnt Agonist
- 中文名:WNT AGONIST 1 (CID11210285 盐酸盐)
- CBNumber:CB42750501
- 分子式:C19H18N4O3
- 分子量:350.37
- MOL File:853220-52-7.mol
- 沸点 :623.4±65.0 °C(Predicted)
- 密度 :1.353±0.06 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :DMSO: soluble20mg/mL, clear
- 酸度系数(pKa) :6.62±0.10(Predicted)
- 形态 :Yellowish sticky solid
- 颜色 :white to beige
WNT AGONIST 1 (CID11210285 盐酸盐)性质、用途与生产工艺
- 生物活性 BML-284 是一种有效的细胞通透性 Wnt 信号激活剂。BML-284 诱导 TCF 依赖的转录活性，其 EC50>700 nM 。
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靶点
EC50: 700 nM (TCF-dependent transcriptional activity)
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体外研究
BML-284 (10 µM; 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen.BML-284 (10 µM; 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group.
Western Blot Analysis
Cell Line: Human gastric cancer cell lines MNK45 and AGS [1] Concentration: 10 µM Incubation Time: 24 hours Result: Induced β-catenin expression and reserved E-cadherin and N-cadherin expression in MNK45 and AGS cells. -
体内研究
BML-284 (10 ng) combines with Pyrimethanil (4 mg/L) could partially rescue the malformed phenotype and cardiac defects induced by Pyrimethanil in Tg (myl7:EGFP) transgenic embryos at 5.5 hpf are transferred into plates with 20 embryos.
- 更新日期：2024/11/08
- 产品编号：HY-19987
- 产品名称：WNT AGONIST 1 (CID11210285 盐酸盐) BML-284
- CAS编号：853220-52-7
- 包装：5mg
- 价格：660元
- 更新日期：2024/11/08
- 产品编号：HY-19987
- 产品名称：WNT AGONIST 1 (CID11210285 盐酸盐) BML-284
- CAS编号：853220-52-7
- 包装：10mM * 1mLin DMSO
- 价格：726元
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6100
- 优势度：58
