水仙环素
- CAS号:29477-83-6
- 英文名:narciclasine
- 中文名:水仙环素
- CBNumber:CB41341322
- 分子式:C14H13NO7
- 分子量:307.26
- MOL File:29477-83-6.mol
- 熔点 :250-252℃
- 沸点 :447.77°C (rough estimate)
- 密度 :1.85±0.1 g/cm3 (20 ºC 760 Torr)
- 折射率 :1.5300 (estimate)
- 储存条件 :Store at -20°C
- 溶解度 :DMSO: ≥10mg/mL
- 酸度系数(pKa) :7.72±0.70(Predicted)
- 形态 :Solid
- 颜色 :white to off-white
水仙环素性质、用途与生产工艺
- 作用 水仙环素能够高选择性地作用于多形性成胶质细胞瘤,其通过显著减少有丝分裂速度而发挥作用,而不是诱导细胞凋亡来抑制多形性成胶质细胞瘤;同时水仙环素也能调节Rho/Rho激酶/LIM激酶/肌动蛋白素信号通路,增强GTP酶RhoA的活性,同时诱导肌动蛋白应力纤维的形成。
- 生物活性 Narciclasine是一种植物生长调节剂。 Narciclasine调节Rho/Rho 激酶/LIM 激酶/cofilin信号传导途径,大大增加GTP酶RhoA活性以及以RhoA依赖性方式诱导肌动蛋白应力纤维形成。
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靶点
ROCK
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体外研究
Narciclasine activates Rho and stress fibers in glioblastoma multiforme cells. The mean IC 50 of ~50 nM calculated on the 6 human glioblastoma multiforme (U373, Hs683, GL19, GL5, GL16, GL17), The mean IC 50 value of 47 nM for Narciclasine across a panel of 60 cancer cell lines. Bioassay-guided fractionation of the A. belladonna extract resulted in the identification of lycorine as the bio-active compound. The IC 50 measured for radicle growth inhibition is 0.1 µM for Narciclasine.
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体内研究
The i.v. regimen of Narciclasine at 1 mg/kg significantly (P=0.02) increases the survival of GL19 glioblastoma multiforme-bearing mice. Narciclasine when given orally at the same dose five times a week for 5 consecutive weeks also significantly increases animal survival in this model (P=0.008). Oral treatment with Narciclasine at 1 mg/kg significantly increases the survival (P=0.004) of Hs683 glioblastoma multiforme-bearing mice. Increasing the number of doses administered per week does not increase the survival of these Hs683 glioblastoma multiforme-bearing mice. Narciclasine appears to show similar increased survival in these models to temozolomide but at appreciable lower doses and following both oral and i.v. administration.
- 化学性质 白色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于水仙。
- 用途 水仙环素具有抗肿瘤,抗脑瘤,细胞毒作用。
- 更新日期:2024/11/08
- 产品编号:HY-16563
- 产品名称:水仙环素 Narciclasine
- CAS编号:29477-83-6
- 包装:1mg
- 价格:1180元
- 更新日期:2024/11/08
- 产品编号:HY-16563
- 产品名称:水仙环素 Narciclasine
- CAS编号:29477-83-6
- 包装:5mg
- 价格:4750元
- 公司名称:Carl Roth offre
- 联系电话:--
- 电子邮件:r.eckert@rothsochiel.fr
- 国家:法国
- 产品数:2361
- 优势度:58