ChemicalBook CAS数据库列表 7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE
7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE
![7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE,37854-59-4,结构式](https://www.chemicalbook.com/CAS/GIF/37854-59-4.gif)
- CAS号:37854-59-4
- 英文名:RO 08-2750
- 中文名:7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE
- CBNumber:CB3844689
- 分子式:C13H10N4O3
- 分子量:270.24
- MOL File:37854-59-4.mol
7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE化学性质
- 储存条件 :Store at -20°C
- 溶解度 :≤2.7mg/ml in DMSO
- 形态 :solid
- 颜色 :Orange
7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE性质、用途与生产工艺
- 生物活性 Ro 08-2750 是一种非肽、可逆的 NGF 抑制剂，能直接结合 NGF，IC50 值为 ~ 1 µM。Ro 08-2750 能抑制 NGF 结合 p75NTR 的优于 TRKA。Ro 08-2750 是选择性的 MSI RNA 结合抑制剂，其作用的 IC50 值为 2.7 μM。
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靶点
IC50: ~1 µM (NGF), 2.7 μM (MSI RNA-binding)
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体外研究
Ro 08-2750 binds to the NGF dimer thereby probably inducing a change in its conformation such that NGF cannot bind to p75 NTR anymore.
Ro 08-2750 (10 nM) completely rescues cells from undergoing NGF-induced SK-N-MC 103 cells death.
Ro 08-2750 (5-10 μM; 8 hours) increases differentiation and apoptosis in myeloid leukemia cells.
Ro 08-2750 inhibits survival of human AML lines and patient cells.
Ro 08-2750 inhibits MSI2 RNA-binding and alters MSI2 gene signature.
Apoptosis Analysis
Cell Line: MLL-AF9 + BM cells Concentration: 5 μM, 10 μM Incubation Time: 8 hours Result: Increased apoptosis. -
体内研究
Ro 08-2750 (13.75 mg/kg; i.p.) inhibits leukemogenesis in a myeloid leukemia model in vivo.
Animal Model: C57BL/6 wild type mice (10-12-weeks-old), MLL-AF9 murine leukemia model Dosage: 13.75 mg/kg Administration: Intraperitoneal injection, at days 1, 4, 7, 10, and 13 (one day on, two days off drug) Result: Inhibited c-MYC levels and reduced disease burden.
7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE上下游产品信息
上游原料
下游产品
7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-108466
- 产品名称：7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE Ro 08-2750
- CAS编号：37854-59-4
- 包装：1mg
- 价格：288元
- 更新日期：2024/11/08
- 产品编号：HY-108466
- 产品名称：7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE Ro 08-2750
- CAS编号：37854-59-4
- 包装：5mg
- 价格：720元
7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE生产厂家
- 公司名称：Service Chemical Inc.
- 联系电话：--
- 电子邮件：sales@chemos-group.com
- 国家：德国
- 产品数：6350
- 优势度：71
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