7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE
7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE
英文名称:RO 08-2750
CAS号:37854-59-4
分子式:C13H10N4O3
分子量:270.24
EINECS号:
Mol文件:37854-59-4.mol
![7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE 结构式](https://img.chemicalbook.com/CAS/GIF/37854-59-4.gif)
7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO 中≤2.7mg/ml |
| 形态 | 固体 |
| 颜色 | 橙色 |
7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE 用途与合成方法
Ro 08-2750 是一种非肽、可逆的 NGF 抑制剂，能直接结合 NGF，IC50 值为 ~ 1 µM。Ro 08-2750 能抑制 NGF 结合 p75NTR 的优于 TRKA。Ro 08-2750 是选择性的 MSI RNA 结合抑制剂，其作用的 IC50 值为 2.7 μM。
IC50: ~1 µM (NGF), 2.7 μM (MSI RNA-binding)
Ro 08-2750 binds to the NGF dimer thereby probably inducing a change in its conformation such that NGF cannot bind to p75
NTR
anymore.
Ro 08-2750 (10 nM) completely rescues cells from undergoing NGF-induced SK-N-MC 103 cells death.
Ro 08-2750 (5-10 μM; 8 hours) increases differentiation and apoptosis in myeloid leukemia cells.
Ro 08-2750 inhibits survival of human AML lines and patient cells.
Ro 08-2750 inhibits MSI2 RNA-binding and alters MSI2 gene signature.
Apoptosis Analysis
| Cell Line: | MLL-AF9 + BM cells |
| Concentration: | 5 μM, 10 μM |
| Incubation Time: | 8 hours |
| Result: | Increased apoptosis. |
Ro 08-2750 (13.75 mg/kg; i.p.) inhibits leukemogenesis in a myeloid leukemia model in vivo.
| Animal Model: | C57BL/6 wild type mice (10-12-weeks-old), MLL-AF9 murine leukemia model |
| Dosage: | 13.75 mg/kg |
| Administration: | Intraperitoneal injection, at days 1, 4, 7, 10, and 13 (one day on, two days off drug) |
| Result: | Inhibited c-MYC levels and reduced disease burden. |
7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-108466 | 7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE | 37854-59-4 | 5mg | 720 |
| 2024-04-30 | HY-108466 | 7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE | 37854-59-4 | 10mM * 1mLin DMSO | 792 |
7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE供应商 更多
河南阿尔法化工有限公司
现货
联系电话：0371-55013243 15324716602
产品介绍：
英文名称：7,10-dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde
CAS：37854-59-4
纯度：98%
包装信息：g；kg
备注：可按需分装，高校、科研单位可先发货后付款，欢迎询价！QQ：2853979810 电话(同微信)：15324716602
库存量：8g
现货日期：2024/4/29 17:03:07
武汉易泰科技有限公司上海分公司
联系电话：821-50328103-801 18930552037
产品介绍：
英文名称：Ro 08-2750;2,3,4,10-Tetrahydro-7,10-diMethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde
CAS：37854-59-4
纯度：99% HPLC
包装信息：1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
上海缮远医药科技有限公司
联系电话：021-31761238 13167072949
产品介绍：
英文名称：RO 08-2750
CAS：37854-59-4
纯度：98%
包装信息：5KG;1KG;500G
备注：原料
常州平博医药研发有限公司
联系电话：0519-83990708
产品介绍：
英文名称：Ro 08-2750;2,3,4,10-Tetrahydro-7,10-diMethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde
CAS：37854-59-4
纯度：95%
包装信息：100mg,500mg,1g,5g,10g,25g,100g,500g,1kg
备注：定制产品
