11B-羟孕酮
- CAS号:600-57-7
- 英文名:11BETA-HYDROXYPROGESTERONE
- 中文名:11B-羟孕酮
- CBNumber:CB3478857
- 分子式:C21H30O3
- 分子量:330.46
- MOL File:600-57-7.mol
- 熔点 :181～184℃
- 沸点 :487.4±45.0 °C(Predicted)
- 密度 :1.15±0.1 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
- 形态 :Solid
- 酸度系数(pKa) :14.52±0.70(Predicted)
- 颜色 :White to Off-White
- 水溶解性 :30.84mg/L(37 ºC)
11B-羟孕酮性质、用途与生产工艺
- 生物活性 11beta-Hydroxyprogesterone是11β-羟基甾类脱氢酶(11β-Hydroxysteroid dehydrogenase)的有效抑制剂; 同时在COS-7细胞中激活人类盐皮质激素受体， ED50 值为10 nM。
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靶点
Human Endogenous Metabolite
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体外研究
11OHP displays agonist mineralocorticoid activity. 11β-hydroxyprogesterone activates the transiently expressed hMR in COS-7 cells in a dose-dependent manner with an ED 50 of 10 nM and stimulates Ams/ sc in mpkCCD cl4 cells. Docking 11β-hydroxyprogesterone within the hMR-ligand-binding domain homology model reveals that the agonist activity of 11OHP is caused by contacts between its 11β-hydroxyl group and Asn770.
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体内研究
11β-hydroxyprogesterone causes a significant elevation in blood pressure within 3 days, an effect that persisted throughout the 14-day infusion. 11β-hydroxyprogesterone is potently hypertensinogenic in the rat and that this activity depends on an intact adrenal and at least in part on the activation of mineralocorticoid receptors.
- 更新日期：2024/11/08
- 产品编号：HY-N2337
- 产品名称：11beta-Hydroxyprogesterone
- CAS编号：
- 包装：1 mg
- 价格：225元
- 更新日期：2024/11/08
- 产品编号：HY-N2337
- 产品名称：11B-羟孕酮 11beta-Hydroxyprogesterone
- CAS编号：600-57-7
- 包装：5mg
- 价格：450元
- 公司名称：SPEC-INF-BB
- 联系电话：--
- 电子邮件：spectrum@kv.ukrtel.net
- 国家：乌克兰
- 产品数：2741
- 优势度：53
