乙基氢化铜蛋白
- CAS号:3413-58-9
- 英文名:ETHYLHYDROCUPREINE HYDROCHLORIDE
- 中文名:乙基氢化铜蛋白
- CBNumber:CB3434170
- 分子式:C21H29ClN2O2
- 分子量:376.92
- MOL File:3413-58-9.mol
- 熔点 :121-123°C
- 比旋光度 :D21 -123.6° (water)
- 储存条件 :2-8°C
- 溶解度 :DMSO : 125 mg/mL (331.64 mM; Need ultrasonic)
- 形态 :Solid
- 颜色 :White to off-white
- 敏感性 :Light Sensitive
- BRN :4055970
- 危险品标志 :Xi
- 危险类别码 :36/37/38
- 安全说明 :22-24/25-36-26
- WGK Germany :3
- RTECS号 :MW6300000
- F :8
- 海关编码 :29392900
乙基氢化铜蛋白性质、用途与生产工艺
- 生物活性 Ethylhydrocupreine hydrochloride (Optochin hydrochloride) 是一种具有抗菌作用的奎宁衍生物，具有抗肺炎链球菌 (S. pneumoniae) 的活性。Ethylhydrocupreine hydrochloride 还具有抗 Plasmodium falciparum 的抗疟活性，IC50 为 25.75 nM。Ethylhydrocupreine hydrochloride 是一种 Gallus gallus 2 受体 (ggTas2r1，ggTas2r2 和 ggTas2r7) 激动剂。
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靶点
S. pneumoniae
IC50: 25.75 nM ( Plasmodium falciparum )
ggTas2r1, ggTas2r2 and ggTas2r7 -
体外研究
The mutation rate to Ethylhydrocupreine (Optochin) resistance is estimated using fluctuation analysis in three capsulated S. pneumoniae strains ( S. pneumoniae D39 NCTC 7466, S. pneumoniae R6 ATCC BAA-255 and S. pneumoniae ATCC 49619). The exposure to subinhibitory concentrations of penicillin increased the mutation rate (expressed as mutation per cell division) to Ethylhydrocupreine (Optochin) resistance between 2.1- and 3.1-fold for all three strains studied.
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体内研究
The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs.
- 用途 鉴定Streptococcuspneumoniae的特效灵敏试剂。
- 更新日期：2024/11/08
- 产品编号：HY-136429A
- 产品名称：乙基氢化铜蛋白 Ethylhydrocupreine hydrochloride
- CAS编号：3413-58-9
- 包装：25mg
- 价格：304元
- 更新日期：2024/11/08
- 产品编号：HY-136429A
- 产品名称：乙基氢化铜蛋白 Ethylhydrocupreine hydrochloride
- CAS编号：3413-58-9
- 包装：50mg
- 价格：480元
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
