乙基氢化铜蛋白

生物活性靶点体外研究体内研究乙基氢化铜蛋白试剂级价格

乙基氢化铜蛋白

CAS号:3413-58-9
英文名:ETHYLHYDROCUPREINE HYDROCHLORIDE
中文名:乙基氢化铜蛋白
CBNumber:CB3434170
分子式:C21H29ClN2O2
分子量:376.92
MOL File:3413-58-9.mol

乙基氢化铜蛋白化学性质

熔点 :121-123°C
比旋光度 :D21 -123.6° (water)
储存条件 :2-8°C
溶解度 :DMSO : 125 mg/mL (331.64 mM; Need ultrasonic)
形态 :Solid
颜色 :White to off-white
敏感性 :Light Sensitive
BRN :4055970

安全信息

危险品标志 :Xi
危险类别码 :36/37/38
安全说明 :22-24/25-36-26
WGK Germany :3
RTECS号 :MW6300000
F :8
海关编码 :29392900

乙基氢化铜蛋白性质、用途与生产工艺

生物活性 Ethylhydrocupreine hydrochloride (Optochin hydrochloride) 是一种具有抗菌作用的奎宁衍生物，具有抗肺炎链球菌 (S. pneumoniae) 的活性。Ethylhydrocupreine hydrochloride 还具有抗 Plasmodium falciparum 的抗疟活性，IC50 为 25.75 nM。Ethylhydrocupreine hydrochloride 是一种 Gallus gallus 2 受体 (ggTas2r1，ggTas2r2 和 ggTas2r7) 激动剂。
靶点

S. pneumoniae
IC50: 25.75 nM ( Plasmodium falciparum )
ggTas2r1, ggTas2r2 and ggTas2r7
体外研究

The mutation rate to Ethylhydrocupreine (Optochin) resistance is estimated using fluctuation analysis in three capsulated S. pneumoniae strains ( S. pneumoniae D39 NCTC 7466, S. pneumoniae R6 ATCC BAA-255 and S. pneumoniae ATCC 49619). The exposure to subinhibitory concentrations of penicillin increased the mutation rate (expressed as mutation per cell division) to Ethylhydrocupreine (Optochin) resistance between 2.1- and 3.1-fold for all three strains studied.
体内研究

The injection of 1 cc. of a 24 hour dextrose blood broth culture of virulent Type I pneumococci into the right pleural cavity of guinea pigs produces acute suppurative pleuritis on both sides associated with suppurative pericarditis. The injection of 1 cc. of 1:500 solutions of Ethylhydrocupreine hydrochloride into each pleural cavity of guinea pigs at varying intervals up to 24 hours after pleural infection has usually shown a marked curative influence. Similar results are observed with dogs.
用途鉴定Streptococcuspneumoniae的特效灵敏试剂。