RP-8-CPT-CAMPS

生物活性靶点体外研究

CAS号:129735-01-9
英文名:8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
中文名:RP-8-CPT-CAMPS
CBNumber:CB3431184
分子式:C16H14ClN5NaO5PS2
分子量:509.86
MOL File:129735-01-9.mol

RP-8-CPT-CAMPS化学性质

安全信息

RP-8-CPT-CAMPS性质、用途与生产工艺

生物活性 Rp-8-CPT-cAMPS，一种 cAMP 类似物，是 cAMP 诱导的依赖 cAMP 的 PKA I 和 PKA II 活化的有效和竞争性的拮抗剂。Rp-8-CPT-cAMPS 优先选择 RI 的位点 A 与 RII 的位点 B。
靶点

PKA
体外研究

Rp-8-CPT-cAMPS (100 μM; 15 min) blocks phosphorylation of VASP by 6-Bnz-cAMP and largely reduces VASP phosphorylation by forskolin and fenoterol.
Rp-8-CPT-cAMPS (100 μM; 30 min) reduces GTP-loading of Rap1 by both 8-pCPT-2'-O-Me-cAMP and 6-Bnz-cAMP.
Rp-8-CPT-cAMPS (100 μM; 30 min) largely diminishes the augmentation of bradykinin-induced IL-8 release by the PKA activator 6-Bnz-cAMP and the Epac activator 8-pCPT-2'-O-Me-cAMP.
Rp-8-CPT-cAMPS (10 μM) inhibits the endothelium-dependent and -independent relaxation which induced by Venom in pre-contracted rat mesenteric artery rings.

RP-8-CPT-CAMPS上下游产品信息

上游原料

下游产品

RP-8-CPT-CAMPS生产厂家