噻唑蓝

噻唑蓝化学性质

熔点 :195 °C (dec.) (lit.)
密度 :1.4886 (estimate)
储存条件 :2-8°C
溶解度 :methanol: 5 mg/mL, clear
形态 :powder
颜色 :Yellow to orange
水溶解性 :Slightly soluble.Clear yellow solution at 5mg in 1ml of water on vortexing
敏感性 :Light Sensitive
最大波长(λmax) :378 nm, 242 nm
BRN :3825277
稳定性 :Hygroscopic
生物领域应用 :Cell viability assay; microbial growth assays; DNA quantification assays; tissue viability assays; detecting enzymes; measuring membrane potential; treating Alzheimer’s disease,asthma,cancer
InChIKey :AZKSAVLVSZKNRD-UHFFFAOYSA-M
CAS 数据库 :298-93-1(CAS DataBase Reference)
EPA化学物质信息 :2H-Tetrazolium, 2-(4,5-dimethyl-2-thiazolyl)-3,5-diphenyl-, bromide (298-93-1)

安全信息

噻唑蓝 MSDS

3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide

生物活性 Thiazolyl Blue (MTT, Tetrazolium bromide, Methylthiazolyldiphenyl-tetrazolium bromide, Methylthialazole Tetrazolium)是一种细胞可渗透且带正电的比色剂，被广泛用于检测细胞中的还原代谢以及测量细胞增殖，细胞毒性和凋亡。Thiazolyl Blue (MTT) 在活细胞中会从黄色还原为紫色的甲臜。
体外研究

Thiazolyl Blue (MTT) is used in conjunction with rhodamine B to measure mitochondrial membrane potential. Thiazolyl Blue-formazan is generated in mitochondria acts as a fluorescence quencher for rhodamine that distributes across membranes of viable cells according to membrane potential. In the absence of mPMS, cellular reduction of Thiazolyl Blue is strong. Thiazolyl Blue is membrane-impermeable when incorporated into large unilamellar liposomes, and therefore it is taken up by cells via endocytosis.
用途 1．药物（也包括其他处理方式如放射线照射）对体外培养的细胞毒性的测定； 2．细胞增殖及细胞活性测定。

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