BD-1047盐酸盐

生物活性靶点体外研究体内研究 BD-1047盐酸盐试剂级价格

BD-1047盐酸盐

CAS号:138356-21-5
英文名:BD 1047 dihydrobromide
中文名:BD-1047盐酸盐
CBNumber:CB32755978
分子式:C13H22Br2Cl2N2
分子量:437.04118
MOL File:138356-21-5.mol

BD-1047盐酸盐化学性质

储存条件 :Inert atmosphere,2-8°C
溶解度 :H2O: >5mg/mL
形态 :powder
颜色 :white
稳定性 :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.

安全信息

危险品标志 :Xi
危险类别码 :37/38-41
安全说明 :26-36/37
WGK Germany :3

BD-1047盐酸盐性质、用途与生产工艺

生物活性 BD-1047 dihydrobromide (HBr) 是一种 sigma-1 (σ1) receptor 的选择性的功能拮抗剂，在动物模型中显示出抗精神病活性，可预测对精神分裂症的疗效。
靶点
Target Value
σ1 receptor
()
体外研究

BD-1047 (dihydrobromide) prevents that Cutamesine reduces the cell death rate induced by light exposure in murine photoreceptor-derived 661w cells.
BD-1047 (dihydrobromide) attenuates that Cutamesine reduces the mitochondrial damage and the elevated level of caspase 3/7 activity.

体内研究

BD-1047 (dihydrobromide) (1-10 mg/kg; i.p.) decreases the Apomorphine (APO)-induced climbing behavior at the dose of 10 mg/kg in mice.
BD-1047 (dihydrobromide) counteracts the antidepressant-like effect induced by co-administration of pramipexole and sertraline (but not pramipexole and fluoxetine).
BD-1047 (dihydrobromide) reduces the increasing expression of pNR1, and reverses the Sig-1 R agonists potentiated NMDA-induced pain behaviour and pNR1 immunoreactivity.

Animal Model:	Male Albino Swiss mice (50 days old, 25–28 g)
Dosage:	1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:	Intraperitoneal injection
Result:	Decreased the APO-induced climbing at the dose of 10 mg/kg in mice.