MAY-262611

MAY-262611化学性质

沸点 :544.8±42.0 °C(Predicted)
密度 :1.169±0.06 g/cm3(Predicted)
储存条件 :under inert gas (nitrogen or Argon) at 2–8 °C
溶解度 :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
形态 :Powder
酸度系数(pKa) :10.13±0.29(Predicted)
颜色 :Light yellow to yellow

MAY-262611性质、用途与生产工艺

生物活性 WAY-262611是 Wnt/β- 联蛋白激动剂，可增加骨形成速率，在 TCF- 荧光素酶测定实验中的 EC50 值为0.63 μM。WAY-262611 也是 Dkk1 的抑制剂。
靶点

EC50: 0.63 μM (β-Catenin)
体外研究

WAY-262611 has the most potent activity in the primary assay, low kinase inhibition potential, and high solubility.
体内研究

WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wnt β -catenin pathway and most likely through inhibition of Dkk-1.

MAY-262611上下游产品信息

上游原料

下游产品

MAY-262611 试剂级价格

MAY-262611生产厂家

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