KONGENSIN A
- CAS号:885315-96-8
- 英文名:Kongensin A
- 中文名:KONGENSIN A
- CBNumber:CB32519820
- 分子式:C22H30O5
- 分子量:374.4706
- MOL File:885315-96-8.mol
- 熔点 :160-162 °C(Solv: chloroform (67-66-3))
- 沸点 :525.7±50.0 °C(Predicted)
- 密度 :1.17±0.1 g/cm3(Predicted)
- 储存条件 :4°C, protect from light
- 形态 :Solid
- 酸度系数(pKa) :13.07±0.70(Predicted)
- 颜色 :White to light yellow
KONGENSIN A性质、用途与生产工艺
- 生物活性 Kongensin A 是一种从 Croton kongensis 中分离的天然产物。 Kongensin A 是一种有效的,共价的 HSP90 抑制剂,可阻断 RIP3 依赖性坏死病。Kongensin A 是一种有效的坏死性抑制剂和凋亡诱导剂,并具有潜在的抗坏死性和消炎性应用。
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靶点
HSP90
RIP3
Apoptosis -
体外研究
Kongensin A (0-15 μM; 6 hours; HT29 cells) treatment induces caspase activation and apoptosis in multiple cancer cell lines in a dosage-dependent manner.
Kongensin A (0-15 μM; 24 hours; HT29 cells) treatment induces the degradation of RIPK1 and oncogenic kinases such as ERBB2, AKT, EGFR, and B-raf, and induces the up-regulation of HSP90A and HSP90B.
Kongensin A covalently binds to cysteine 420 in the middle domain of HSP90 and dissociates HSP90 from its cochaperone CDC37. The HSP90-CDC37 complex is required for RIP3 activation, KA blocks LPS/Smac mimetics/Z-VAD and RIP3 polymerization-induced cell death, in which cell death is dependent on RIP3 but not its upstream kinase RIP1.Apoptosis Analysis
Cell Line: HT29 cells Concentration: 0 μM, 2.5 μM, 5 μM, 15 μM Incubation Time: 6 hours Result: Induced caspase activation and apoptosis in a dosage-dependent manner. Western Blot Analysis
Cell Line: HT29 cells Concentration: 0 μM, 2.5 μM, 5 μM, 15 μM Incubation Time: 24 hours Result: Induced the degradation of RIPK1 and oncogenic kinases such as ERBB2, AKT, EGFR, and B-raf, and induced the up-regulation of HSP90A and HSP90B.
- 更新日期:2025/02/08
- 产品编号:HY-N3417
- 产品名称:KONGENSIN A Kongensin A
- CAS编号:885315-96-8
- 包装:1 mg
- 价格:9500元
- 更新日期:2023/03/20
- 产品编号:HY-N3417
- 产品名称:KONGENSIN A Kongensin A
- CAS编号:885315-96-8
- 包装:5 mg
- 价格:20800元
- 公司名称:EMMX Biotechnology LLC
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- 公司名称:MedChemExpress
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