生物活性 体外研究 体内研究 扑蛲灵 试剂级价格
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扑蛲灵

扑蛲灵,3546-41-6,结构式
扑蛲灵
  • CAS号:3546-41-6
  • 英文名:PYRVINIUM PAMOATE
  • 中文名:扑蛲灵
  • CBNumber:CB3249600
  • 分子式:C75H70N6O6
  • 分子量:1151.39
  • MOL File:3546-41-6.mol
扑蛲灵化学性质
  • 熔点 :210-215° (softens at 190°)
  • 沸点 :829.27°C (rough estimate)
  • 密度 :1.0104 (rough estimate)
  • 折射率 :1.6400 (estimate)
  • 储存条件 :2-8°C
  • 溶解度 :DMSO: >10mg/mL
  • 形态 :powder
  • 颜色 :red
  • EPA化学物质信息 :Pyrvinium pamoate (3546-41-6)
安全信息

扑蛲灵性质、用途与生产工艺

  • 生物活性 Pyrvinium是一种驱虫剂,对蛲虫有效。
  • 体外研究

    Pyrvinium pamoate (0-500 nM) inhibits proliferation of MCF-7 (luminal), MDA-MB-231 (claudin-low), MDA-MB-468 (basal-like) and SkBr3 (HER2-OE) cells in a dose-dependent manner, with IC 50 value of 1170±105.0 nM against MDA-MB-231 cell line. Pyrvinium pamoate significantly inhibits self-renewal and proliferation of BCSCs, and suppresses BCSC population with a distinct phenotype. Pyrvinium pamoate significantly decreases average expression levels of FZD1, FZD10, WNT1, WNT7B, CTNNB1, MYC, and LRP5 at transcriptional level. Moreover, Pyrvinium pamoate also efficiently down-regulates the expression of other stemness genes including ALDH1, CD44 and ABCG2. Pyrvinium pamoate blocks colon cancer cell growth in vitro in a dose-dependent manner with great differences in the inhibitory concentration (IC 50 ), ranging from 0.6 to 65 μM for colon cancer cells with mutations in WNT signaling. Pyrvinium pamoate decreases messenger RNA (mRNA) and protein levels of known WNT target genes as c-MYC and thereby led to the induction of p21. Pyrvinium pamoate ultimately inhibits Wnt signalling despite its lack of efficacy on CK1. Pyrvinium pamoate imposes specific toxicity on cardiac fibroblasts in ischemia (IC 50 =9.5 nM). The cytotoxic effect of Pyrvinium pamoate on cardiac fibroblasts specifically under glucose- and glutamine-deficient condition.

  • 体内研究

    In the xenograft model, Pyrvinium pamoate (500 nM)-pretreatment strongly delays tumor size and tumor weight, and the tumor volume is markedly decreased.

扑蛲灵上下游产品信息
上游原料
下游产品
扑蛲灵 试剂级价格
  • 更新日期:2024/01/25
  • 产品编号:HY-A0293
  • 产品名称:Pyrvinium pamoate
  • CAS编号:
  • 包装:1 mg
  • 价格:171元
  • 更新日期:2024/01/25
  • 产品编号:HY-A0293
  • 产品名称:Pyrvinium pamoate
  • CAS编号:
  • 包装:5 mg
  • 价格:343元
扑蛲灵生产厂家
  • 公司名称:MedChemexpress LLC
  • 联系电话:021-58955995
  • 电子邮件:sales@medchemexpress.cn
  • 国家:美国
  • 产品数:4863
  • 优势度:58
  • 公司名称:TargetMol中国(陶术生物)
  • 联系电话:021-33632979 15002134094
  • 电子邮件:marketing@targetmol.com
  • 国家:中国
  • 产品数:7934
  • 优势度:58
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