新植二烯
- CAS号:504-96-1
- 英文名:7,11,15-trimethyl-3-methylidene-hexadec-1-ene
- 中文名:新植二烯
- CBNumber:CB31456498
- 分子式:C20H38
- 分子量:278.52
- MOL File:504-96-1.mol
- 沸点 :144-146 °C(Press: 3.5 Torr)
- 密度 :0.8168 g/cm3
- 储存条件 :-20°C Freezer
- 溶解度 :Benzene (Slightly), Chloroform (Soluble), Ethyl Acetate (Slightly)
- 形态 :Oil
- 颜色 :Colourless
- 稳定性 :Light Sensitive, Temperature Sensitive
- LogP :9.522 (est)
- EPA化学物质信息 :1-Hexadecene, 7,11,15-trimethyl-3-methylene- (504-96-1)
新植二烯性质、用途与生产工艺
- 生物活性 Neophytadiene 是一种二萜，能从 Turbinaria ornate 中提取到，具有抗炎、抗氧化和心脏保护作用。
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体外研究
Neophytadiene has cytotoxic on RAW 264.7 cells with an IC 50 of 50 μM.
Neophytadiene (50-100 μM; 30 min) successfully inhibits the NO production level and downregulated inducible nitric oxide synthase (iNOS) production in LPS (1 μg/mL)-induced RAW264.7 cells.
Neophytadiene (25-100 μM; 22 hours) significantly inhibits the NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in LPS (1 μg/mL)-induced RAW264.7 cells.
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体内研究
Neophytadiene (50 mg/kg; p.o.) shows dose-dependent reduction in the alanine aminotransferase (ALT) level.
Neophytadiene (25-50 mg/kg; p.o.) significantly reduces LPS (10 mg/kg)-increased IL6 and 1L10 levels and in heart tissue.
Neophytadiene (25-50 mg/kg; p.o.) significantly reduces LPS (10 mg/kg)-increased PGE2mRNA expression in heart tissue.
Neophytadiene significantly inhibits LPS (10 mg/kg)-induced NO production and inflammatory cytokines TNF-α, IL-6 and IL-10 and IL-10 in vivo.
Animal Model: Adult male Sprague Dawley rats (6-8 weeks) Dosage: 12 mg/kg, 25 mg/kg, 50 mg/kg Administration: Oral administration, daily, for 7 days Result: Decreased haemoglobin (HGB) level, ALT level, and heart tissue TNF-α, IL1β, NF-κB, iNOS, PI3k/AktandMAPK in LPS (10 mg/kg)-treat rats.
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