N-单甲基-L-精氨酸单乙酸酯
- CAS号:53308-83-1
- 英文名:NG-MONOMETHYL-L-ARGININE ACETATE
- 中文名:N-单甲基-L-精氨酸单乙酸酯
- CBNumber:CB3138560
- 分子式:C9H20N4O4
- 分子量:248.28
- MOL File:53308-83-1.mol
- 熔点 :180-190 °C
- 比旋光度 :D22 +9.5° (c = 0.10 in water)
- 沸点 :391.35°C (rough estimate)
- 密度 :1.2162 (rough estimate)
- 折射率 :1.6300 (estimate)
- 储存条件 :2-8°C
- 溶解度 :H2O: 1 mg/mL, clear, colorless
- 形态 :Powder
- 颜色 :White to Off-white
- 水溶解性 :Soluble in water (50 mM)
- BRN :6674255
- 稳定性 :Store at - 5°C; Desiccate Recommended
- InChIKey :IKPNWIGTWUZCKM-JEDNCBNOSA-N
- 安全说明 :22-24/25
- WGK Germany :3
- 海关编码 :29252900
N-单甲基-L-精氨酸单乙酸酯性质、用途与生产工艺
- 生物活性 L-NMMA acetate是一氧化氮合酶 (nitric oxide synthase) 抑制剂, 抑制一氧化氮合酶的所有亚型NOS1，NOS2和NOS3。对nNOS (大鼠), eNOS (人), and iNOS (小鼠) 的Ki 值分别为0.18，0.4，6 µM。
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靶点
Ki: 0.18 µM (nNOS), 0.4 µM (eNOS), 6 µM (iNOS)
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体外研究
L-NMMA, starting from 100 μM, produces a concentration-dependent inhibition of the evoked relaxations (2Hz); maximal inhibition at 1 mM averaged about 35%. The inhibitory effect of L-NMMA is unchanged by previous incubation with D-arginine while it is prevented by L-arginine (L-Arg). L-NMMA does not affect isoprenaline-induced relaxation. Superfusion of L-NMMA reduces arteriolar diameter and causes dose-dependent increases in arteriolar tone. The onset of action of L-NMMA is nearly immediate. L-NMMA inhibits vasodilator responses to the endothelium-dependent vasodilator ACh but not to the endothelium-independent NP. NE induced dose-related vasoconstriction that is significantly potentiated by L-NMMA.
- 更新日期：2024/11/08
- 产品编号：32872
- 产品名称：NG—单甲基—L—精氨酸醋酸盐 100MG N-omega-Monomethyl-L-arginine monoacetate, 99%
- CAS编号：53308-83-1
- 包装：5mg
- 价格：607元
- 更新日期：2024/11/08
- 产品编号：32872
- 产品名称：NG—单甲基—L—精氨酸醋酸盐 100MG N-omega-Monomethyl-L-arginine monoacetate, 99%
- CAS编号：53308-83-1
- 包装：25mg
- 价格：1744元
- 公司名称：Acros Organics
- 联系电话：--
- 电子邮件：info@acros.com
- 国家：比利时
- 产品数：6772
- 优势度：81
