小豆蔻明
- CAS号:19309-14-9
- 英文名:CARDAMONIN
- 中文名:小豆蔻明
- CBNumber:CB31092214
- 分子式:C16H14O4
- 分子量:270.28
- MOL File:19309-14-9.mol
- 熔点 :199~200℃
- 沸点 :484.5±45.0 °C(Predicted)
- 密度 :1.282±0.06 g/cm3(Predicted)
- 储存条件 :room temp
- 溶解度 :DMSO: ≥20mg/mL
- 酸度系数(pKa) :7.00±0.40(Predicted)
- 形态 :powder
- 颜色 :yellow
- 稳定性 :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 weeks.
小豆蔻明性质、用途与生产工艺
- 理化性质 小豆蔻明(Cardamonin),为黄色针晶,易溶于甲醇、乙醇、醋酸乙酯,乙醚,稀碱溶液,难溶于水,与醋酸铅反应呈黄色沉淀。小豆蔻明可以明显抑制络氨酸酶的活性,同时可以有效抑制黑色素细胞增殖和黑色素的合成,效果明显超过其他成分。
- 生物活性 (E)-Cardamonin ((E)-Cardamomin) 是新颖的hTRPA1阳离子通道拮抗剂,IC50值为454 nM。
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靶点
Target Value NF-κB
(Cell-free assay)TRPA1
(Cell-free assay)454 nM -
体外研究
(E)-Cardamonin ((E)-Cardamomin) selectively blocksTRPA1 activation (IC 50 =454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. (E)-Cardamonin ((E)-Cardamomin) does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction. (E)-Cardamonin ((E)-Cardamomin) suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells.
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体内研究
(E)-Cardamonin ((E)-Cardamomin) (3-30 mg/kg, orally administered) significantly inhibits PBQ-induced writhing. CDN also produces a significant, dose-dependent increase in the withdrawal response latencies in carrageenan-induced hyperalgesia.
- 化学性质 黄色结晶性粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于草豆蔻。
- 用途 小豆蔻明具有抗菌、止呕、健脾的作用。
- 用途 用于含量测定/鉴定/药理实验等
- 更新日期:2024/11/08
- 产品编号:HY-N1378
- 产品名称:小豆蔻明 (E)-Cardamonin
- CAS编号:19309-14-9
- 包装:5mg
- 价格:246元
- 更新日期:2024/11/08
- 产品编号:HY-N1378
- 产品名称:小豆蔻明 (E)-Cardamonin
- CAS编号:19309-14-9
- 包装:10mg
- 价格:400元
- 公司名称:CFMOT-PHYTO
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- 国家:德国
- 产品数:1136
- 优势度:62