ChemicalBook CAS数据库列表 L-161,982
L-161,982
- CAS号:147776-06-5
- 英文名:L-161,982
- 中文名:L-161,982
- CBNumber:CB31074878
- 分子式:C32H29F3N4O4S2
- 分子量:654.72
- MOL File:147776-06-5.mol
L-161,982化学性质
- 密度 :1.37±0.1 g/cm3(Predicted)
- 储存条件 :2-8°C
- 溶解度 :DMSO: soluble15mg/mL, clear
- 酸度系数(pKa) :4.57±0.10(Predicted)
- 形态 :powder
- 颜色 :white to beige
安全信息
- WGK Germany :3
L-161,982性质、用途与生产工艺
- 生物活性 L-161982 是一种选择性的 EP4 受体拮抗剂。L-161982 完全阻断 PGE2 诱导的 HCA-7 细胞 ERK 磷酸化和细胞增殖。L-161982 减轻胶原诱导的小鼠关节炎。
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靶点
EP4
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体外研究
L-161982 (10 μM; 2 hours) blocks PGE2-stimulated cell proliferation of HCA-7 cells.
L-161982 (10 μM; 1 hour) blocks PGE2-stimulated ERK phosphorylation in HCA-7 cells.
L-161982 induces apoptosis, cell cycle arrest, and inhibits prostaglandin E2-induced proliferation in oral squamous carcinoma Tca8113 cells.Cell Proliferation Assay
Cell Line: HCA-7 cells Concentration: 10 μM Incubation Time: 2 hours Result: Blocked PGE2-induced cell proliferation. -
体内研究
L-161982 (5 mg/kg; i.p.; once per day for 2 weeks) reduces arthritis lesions and lesion progression in CIA mice.
Animal Model: Female DBA/1 mice of 6 to 8 weeks old (collagen-induced arthritis (CIA) mice model) Dosage: 5 mg/kg Administration: i.p.; once per day for 2 weeks Result: Showed less joint swelling and lower arthritis score after 35 days post immunization.
L-161,982上下游产品信息
上游原料
下游产品
L-161,982生产厂家
- 公司名称：Service Chemical Inc.
- 联系电话：--
- 电子邮件：sales@chemos-group.com
- 国家：德国
- 产品数：6350
- 优势度：71
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