去水淫羊藿黄素
- CAS号:118525-40-9
- 英文名:Icaritin
- 中文名:去水淫羊藿黄素
- CBNumber:CB2982508
- 分子式:C21H20O6
- 分子量:368.38
- MOL File:118525-40-9.mol
- 熔点 :239℃
- 沸点 :582.0±50.0 °C(Predicted)
- 密度 :1.359
- 闪点 :206.7℃
- 储存条件 :2-8°C
- 溶解度 :DMSO: soluble5mg/mL, clear (warmed)
- 形态 :powder
- 酸度系数(pKa) :6.44±0.40(Predicted)
- 颜色 :light yellow to dark yellow
- 最大波长(λmax) :368nm(MeOH)(lit.)
- InChI :InChI=1S/C21H20O6/c1-11(2)4-9-14-15(22)10-16(23)17-18(24)19(25)20(27-21(14)17)12-5-7-13(26-3)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3
- InChIKey :TUUXBSASAQJECY-UHFFFAOYSA-N
- SMILES :C1(C2=CC=C(OC)C=C2)OC2=C(C/C=C(/C)\C)C(O)=CC(O)=C2C(=O)C=1O
- WGK Germany :3
- RTECS号 :DJ3100870
- 海关编码 :29329990
去水淫羊藿黄素性质、用途与生产工艺
- 生物活性 Icaritin (Anhydroicaritin) 是 Epimedium Genusis 的异戊二烯类黄酮衍生物，有效抑制 K562 细胞 (IC50 为 8 µM) 和原代 CML 细胞 (对 CML-CP 的 IC50 值为 13.4 µM，对 CML-BC 的 IC50 值为 18 µM) 的增殖。Icaritin 可以调节 MAPK/ERK/JNK 和 JAK2/STAT3/AKT 信号传导，并具有增强成骨的作用。
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体外研究
Icaritin (4-64 µM; 48 hours; K562, imatinib-resistant cells and primary CML cells) treatment inhibits proliferation of K562, imatinib-resistant cells and primary CML cells .
Icaritin (0-64 µM; 48 hours; K562 and primary cells) treatment induces K562 or primary cells apoptosis in an concentration dependent manner.
Icaritin (32 µM; K562 cells) treatment increases cell population in the sub-G1 phase in K562 cells.
Icaritin (0-64 µM; 48 hours; K562 cells) treatment inhibits MAPK/ERK/JNK downstream signaling and diminishes Jak2/Stat3/Akt expression. Icaritin treatment also significantly inhibits Bcl-2 protein expression and up-regulated Bax protein expression in K562 with a dose-dependent manner accompanied by the cleavage activation of caspase-3 or caspase-9, and a down-regulated expression of Apaf-1.Cell Proliferation Assay
Cell Line: K562, imatinib-resistant cells and primary CML cells Concentration: 4 µM, 8 µM, 16 µM, 32 µM and 64 µM Incubation Time: 48 hours Result: Inhibited cell proliferation. Apoptosis Analysis
Cell Line: K562 or primary cells Concentration: 0 µM, 4 µM, 8 µM, 16 µM, 32 µM and 64 µM Incubation Time: 48 hours Result: Induced K562 or primary cells apoptosis. Cell Cycle Analysis
Cell Line: K562 cells Concentration: 32 µM Incubation Time: Result: Cell population in the sub-G1 phase was increased. Western Blot Analysis
Cell Line: K562 cells Concentration: 0 µM, 4 µM, 8 µM, 16 µM, 32 µM and 64 µM Incubation Time: 48 hours Result: Inhibited MAPK/ERK/JNK downstream signaling and diminishes Jak2/Stat3/Akt expression. -
体内研究
Icaritin (4-8 mg/kg; intraperitoneal injection; daily; for 10 weeks; female NOD-SCID nude mice) treatment could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells without suppression of bone marrow in mouse leukemia model.
Animal Model: Female NOD-SCID nude mice (6-8 weeks old) with K562 cells Dosage: 4 mg/kg and 8 mg/kg Administration: Intraperitoneal injection; daily; for 10 weeks Result: Could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells without suppression of bone marrow. - 化学性质 黄色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于淫羊藿。
- 用途 具有降压，抗放射性软组织损伤的作用。
- 用途 用于含量测定/鉴定/药理实验等。
- 更新日期：2024/11/08
- 产品编号：HY-N0678
- 产品名称：Icaritin
- CAS编号：
- 包装：1 mg
- 价格：300元
- 更新日期：2024/11/08
- 产品编号：HY-N0678
- 产品名称：去水淫羊藿黄素 Icaritin
- CAS编号：118525-40-9
- 包装：5mg
- 价格：600元
- 公司名称：TOKYO CHEMICAL INDUSTRY CO., LTD.
- 联系电话：03-36680489
- 电子邮件：Sales-JP@TCIchemicals.com
- 国家：日本
- 产品数：28387
- 优势度：80
