托麦汀
- CAS号:26171-23-3
- 英文名:Tolmetin
- 中文名:托麦汀
- CBNumber:CB2875183
- 分子式:C15H15NO3
- 分子量:257.28
- MOL File:26171-23-3.mol
- 熔点 :156 °C
- 沸点 :400.53°C (rough estimate)
- 密度 :1.1391 (rough estimate)
- 折射率 :1.5200 (estimate)
- 储存条件 :2-8°C
- 溶解度 :Chloroform (Slightly), Methanol (Slightly)
- 形态 :Solid
- 酸度系数(pKa) :pKa 3.5(H2O t undefined I undefined) (Uncertain)
- 颜色 :Off-White to Pale Yellow
- 水溶解性 :222 mg/L
- NIST化学物质信息 :Tolmetin(26171-23-3)
- EPA化学物质信息 :1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)- (26171-23-3)
托麦汀 MSDS
2-[1-Methyl-5-(4-methylbenzoyl)-pyrrol-2-yl]acetic acid
托麦汀性质、用途与生产工艺
- 生物活性 Tolmetin (Tolectin) 是一种非类固醇的抗炎药，属于杂环乙酸衍生物类，具有止痛和退热作用。
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靶点
Human COX-1
0.35 μM (IC 50 )
Human COX-2
0.82 μM (IC 50 )
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体外研究
Tolmetin (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat.
Tolmetin (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner.
Tolmetin (0-100 μM) shows no effect on osteoblast growth.
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体内研究
Tolmetin (30,100 mg/kg; gavage; single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg.
Tolmetin (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity.
- 更新日期：2024/11/11
- 产品编号：XW261712331
- 产品名称：托麦汀
- CAS编号：26171-23-3
- 包装：1G
- 价格：197元
- 更新日期：2024/11/08
- 产品编号：HY-B1799
- 产品名称：Tolmetin
- CAS编号：
- 包装：5 mg
- 价格：230元
- 公司名称：Euticals S.p.A.
- 联系电话：--
- 电子邮件：info@euticals.com
- 国家：意大利
- 产品数：86
- 优势度：50
