螺哌丙苯
- CAS号:510-74-7
- 英文名:AMI-193
- 中文名:螺哌丙苯
- CBNumber:CB2728009
- 分子式:C22H26FN3O2
- 分子量:383.46
- MOL File:510-74-7.mol
- 熔点 :176 - 179°C
- 储存条件 :Store at RT
- 溶解度 :DMSO (Slightly), Methanol (Slightly)
- 形态 :White solid.
- 颜色 :Off-White to Pale Yellow
螺哌丙苯性质、用途与生产工艺
- 生物活性 Spiramide (AMI-193) 是一种有效和选择性的 5-HT2 和 dopamine D2 受体拮抗剂，Ki 值分别为 2 nM 和 3 nM。Spiramide 对 5-HT2 受体的选择性与 5-HT1C 受体 (Ki=4300 nM) 相比大于 2000 倍。Spiramide 具有抗精神病活性。
-
靶点
5-HT 2 Receptor
2 nM (Ki)
D 2 Receptor
3 nM (Ki)
5-HT 1A Receptor
50 nM (Ki)
D 1 Receptor
2530 nM (Ki)
5-HT 1C Receptor
4300 nM (Ki)
-
体外研究
Spiramide retains affinity for 5-HT 1A sites (K i =50 nM) and also binds at dopamine D2 sites (K i =3 nM), but possesses low affinity for dopamine D1 sites (K i =2530 nM).
-
体内研究
AMI-193 (0.003-0.01 mg/kg; i.m.) dose-dependently decreases response rate in monkeys under a fixed-interval (FI) schedule of stimulus termination.
AMI-193 (0.003-0.01 mg/kg; i.m.) attenuates the discriminative-stimulus effects of cocaine in drug-discrimination experiments.
AMI-193 (0.003-0.01 mg/kg; i.m.) reduces response rate under a second-order schedule of i.v. self-administration of cocaine (0.1 mg/infusion).Animal Model: Adult male squirrel monkeys (850-1300 g) Dosage: 0.003, 0.01 mg/kg Administration: I.m. on Tuesday, Wednesday, and Thursday the following week Result: Decreased the response rate.
The rate-decreasing effects were reversed by cocaine.
- 更新日期：2024/11/08
- 产品编号：HY-100971
- 产品名称：螺哌丙苯 Spiramide
- CAS编号：510-74-7
- 包装：5mg
- 价格：800元
- 更新日期：2024/11/08
- 产品编号：HY-100971
- 产品名称：螺哌丙苯 Spiramide
- CAS编号：510-74-7
- 包装：10mM * 1mLin DMSO
- 价格：880元
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
- 公司名称：MOLEKULA
- 联系电话：--
- 电子邮件：kevinbanks@molekula.com
- 国家：英国
- 产品数：6140
- 优势度：66
