螺哌丙苯 用途与合成方法
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5-HT 2 Receptor 2 nM (Ki) |
D 2 Receptor 3 nM (Ki) |
5-HT 1A Receptor 50 nM (Ki) |
D 1 Receptor 2530 nM (Ki) |
5-HT 1C Receptor 4300 nM (Ki) |
Spiramide retains affinity for 5-HT 1A sites (K i =50 nM) and also binds at dopamine D2 sites (K i =3 nM), but possesses low affinity for dopamine D1 sites (K i =2530 nM).
AMI-193 (0.003-0.01 mg/kg; i.m.) dose-dependently decreases response rate in monkeys under a fixed-interval (FI) schedule of stimulus termination.
AMI-193 (0.003-0.01 mg/kg; i.m.) attenuates the discriminative-stimulus effects of cocaine in drug-discrimination experiments.
AMI-193 (0.003-0.01 mg/kg; i.m.) reduces response rate under a second-order schedule of i.v. self-administration of cocaine (0.1 mg/infusion).
| Animal Model: | Adult male squirrel monkeys (850-1300 g) |
| Dosage: | 0.003, 0.01 mg/kg |
| Administration: | I.m. on Tuesday, Wednesday, and Thursday the following week |
| Result: |
Decreased the response rate.
The rate-decreasing effects were reversed by cocaine. |
螺哌丙苯 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-02-08 | HY-100971 | 螺哌丙苯 | 510-74-7 | 10mM * 1mLin DMSO | 413 |
| 2025-02-08 | HY-100971 | 螺哌丙苯 | 510-74-7 | 5mg | 489 |
