生物活性 靶点 体外研究 TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS 试剂级价格
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TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS

生物活性 靶点 体外研究 TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS 试剂级价格
TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS,117041-96-0,结构式
TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS
  • CAS号:117041-96-0
  • 英文名:Trisodium (2RS,3RS)-2-methylcitrate
  • 中文名:TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS
  • CBNumber:CB24739711
  • 分子式:C7H7O7*3Na
  • 分子量:230.15
  • MOL File:117041-96-0.mol
TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS化学性质
  • 储存条件 :Store at -20°C
  • 形态 :Solid
  • 颜色 :White to off-white
安全信息
  • WGK Germany :3

TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS性质、用途与生产工艺

  • 生物活性 2-Methylcitric acid trisodium (Methylcitric acid trisodium) 是 2- 甲基柠檬酸循环的内源性代谢物。2-Methylcitric acid trisodium 在甲基丙二酸血症和丙二酸酸血症中积累并能作为代谢标志物。2-Methylcitric acid trisodium 对谷氨酸支持的线粒体中 ADP 刺激和不耦合呼吸作用有明显的抑制作用。
  • 靶点

    Human Endogenous Metabolite

  • 体外研究

    2-Methylcitric acid trisodium impairs glutamate metabolism and induces permeability transition in brain mitochondria.
    2-Methylcitric acid trisodium inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM.
    2-Methylcitric acid trisodium (1 mM, 3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca 2+ -loaded mitochondria supported by different substrates.
    2-Methylcitric acid trisodium behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis.
    2-Methylcitric acid trisodium does not significantly impair mitochondrial glutamate transport.
    2-Methylcitric acid trisodium does not significantly impair glutamate mitochondrial transport in liver mitochondria.

TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS上下游产品信息
上游原料
下游产品
TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：HY-113371A
  • 产品名称：2-Methylcitric acid trisodium
  • CAS编号：
  • 包装：1 mg
  • 价格：1250元
  • 更新日期：2024/11/08
  • 产品编号：HY-113371A
  • 产品名称：TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS 2-Methylcitric acid trisodium
  • CAS编号：117041-96-0
  • 包装：5mg
  • 价格：3500元
TRISODIUM 2-METHYLCITRATE, RACEMIC MIXTURE OF DIASTEREOMERS生产厂家
  • 公司名称：TargetMol Chemicals Inc.
  • 联系电话：+1-781-999-5354 +1-00000000000
  • 电子邮件：marketing@targetmol.com
  • 国家：美国
  • 产品数：32161
  • 优势度：58
  • 公司名称：上海稳同科技有限公司
  • 联系电话：021-021-51600108 13062666369
  • 电子邮件：sales@chinaisotope.com
  • 国家：中国
  • 产品数：4271
  • 优势度：58
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