ChemicalBook CAS数据库列表 氯非铵甲苯磺酸盐
氯非铵甲苯磺酸盐
- CAS号:92953-10-1
- 英文名:CLOFILIUM TOSYLATE
- 中文名:氯非铵甲苯磺酸盐
- CBNumber:CB2435110
- 分子式:C28H44ClNO3S
- 分子量:510.17
- MOL File:92953-10-1.mol
氯非铵甲苯磺酸盐化学性质
- 储存条件 :4°C, protect from light
- 溶解度 :H2O: soluble
- 形态 :solid
- 颜色 :white
安全信息
氯非铵甲苯磺酸盐性质、用途与生产工艺
- 生物活性 Clofilium tosylate 是一种钾通道 (potassium channel) 阻滞剂，作用于人早幼粒细胞白血病 (HL-60) 细胞，激活 caspase-3 而诱导凋亡。具有抗心律失常作用。
-
靶点
Potassium channel
-
体外研究
HL-60 cells treated with Clofilium (0-20 μM; 24, 48, and 72 hours) lead to suppression of viability and proliferation in both time and concentration-dependent manners. Cell viability decreases significantly in HL-60 cells treated with 2.5 μM to 10 μM of Clofilium.
Clofilium (10 μM, 12 hours) induces the proteolytic cleavage of inactive procaspase-3, p34 into its active form, p17 and subsequent cleavage of its substrate PARP at 2 h after exposure to 10 mM Clofilium. However, there is no significant change in expression of Bcl-2 and Bax proteins.Cell Viability Assay
Cell Line: HL-60 cells Concentration: 0-20 μM Incubation Time: 24, 48, and 72 hours Result: Inhibited HL-60 cells with IC 50 s of 6.3 μM for 24 hours, 3.4 μM for 48 hours, 2.4 μM for 72 hours, respectively. Western Blot Analysis
Cell Line: HL-60 cells Concentration: 10 μM Incubation Time: 12 hours Result: Induced proteolytic cleavage of caspase-3 and subsequent cleavage of its substrate, PARP, while Bcl-2 and Bax proteins were unaltered.
氯非铵甲苯磺酸盐上下游产品信息
上游原料
下游产品
氯非铵甲苯磺酸盐 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-33350
- 产品名称：Clofilium tosylate
- CAS编号：
- 包装：1 mg
- 价格：308元
- 更新日期：2024/11/08
- 产品编号：HY-33350
- 产品名称：Clofilium tosylate
- CAS编号：
- 包装：5 mg
- 价格：728元
氯非铵甲苯磺酸盐生产厂家
- 公司名称：Service Chemical Inc.
- 联系电话：--
- 电子邮件：sales@chemos-group.com
- 国家：德国
- 产品数：6350
- 优势度：71
92953-10-1, 氯非铵甲苯磺酸盐相关搜索:
