N-辛酰基-D-神经鞘氨醇
- CAS号:74713-59-0
- 英文名:C8 CERAMIDE
- 中文名:N-辛酰基-D-神经鞘氨醇
- CBNumber:CB2432038
- 分子式:C26H51NO3
- 分子量:425.69
- MOL File:74713-59-0.mol
- 熔点 :68-70°C
- 沸点 :541.37°C (rough estimate)
- 密度 :0.9974 (rough estimate)
- 折射率 :1.6000 (estimate)
- 储存条件 :−20°C
- 溶解度 :DMSO or ethanol: soluble
- 形态 :waxy solid
- 颜色 :White
- 稳定性 :Temperature Sensitive
- CAS 数据库 :74713-59-0(CAS DataBase Reference)
- 安全说明 :24/25
- WGK Germany :3
- 海关编码 :29225000
N-辛酰基-D-神经鞘氨醇性质、用途与生产工艺
- 生物活性 C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) 是一种细胞渗透性的内源性神经酰胺类似物。C8-Ceramide 具有具有抗增殖特性，能作为化疗试剂。C8-Ceramide 能刺激树突状细胞促进 T 细胞对病毒感染的反应。C8-Ceramide 在体外能轻微地诱导 PKC 活化。
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靶点
PKC
apoptosis
autophagy
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体外研究
C8-ceramide (3 μM; 48 hours) irreversibly reduces tumor-cell proliferation and induces morphological changes.
C8-ceramide can induce necrosis-like cell death, but does not induce caspase-dependent cleavage of PARP (biochemical marker of apoptosis) in human cervical tumor cells.
C8-ceramide may increase the endogenous ROS level (10-30 µM; 24 hours) by regulating the switch of SOD1 and SOD2, causing the anti-proliferation (10-50 µM; 24 hours), and consequently triggering the apoptosis (10-50 µM; 48 hours) of NSCLC H1299 cells.
Cell Viability Assay
Cell Line: CALO cells, INBL cells, HeLa cells Concentration: 3 μM Incubation Time: 48 hours Result: Markedly reduced the tumor cell number. Cell Proliferation Assay
Cell Line: H1299 cells Concentration: 10 µM, 20 µM, 30 µM, 40 µM, 50 µM Incubation Time: 24 hours Result: Decreased the rate of cellular proliferation in a dose-dependent manner, with an IC 50 of 22.9 µM. Cell Cycle Analysis
Cell Line: H1299 cells Concentration: 10 µM, 20 µM, 30 µM, 40 µM, 50 µM Incubation Time: 24 hours Result: Caused the G1 arrest. Apoptosis Analysis
Cell Line: H1299 cells Concentration: 10 µM, 20 µM, 30 µM Incubation Time: 24 hours, 48 hours Result: Increased the level of cleaved caspase-3. -
体内研究
C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8 + and CD4 + T cell responses to viral infections in virus infected mice.
Animal Model: C57BL/6 mice, with lymphocytic choriomeningitis virus infected Dosage: 0.1 mg/kg Administration: Intranasal administration Result: Increased the CD8 + T cell response to influenza in the lungs.
- 更新日期：2024/08/19
- 产品编号：HY-108391
- 产品名称：N-辛酰基-D-神经鞘氨醇 C8-Ceramide
- CAS编号：74713-59-0
- 包装：5mg
- 价格：950元
- 更新日期：2024/08/19
- 产品编号：HY-108391
- 产品名称：N-辛酰基-D-神经鞘氨醇 C8-Ceramide
- CAS编号：
- 包装：10 mg
- 价格：1650元
- 公司名称：KANTO
- 联系电话：--
- 电子邮件：reag-info@gms.kanto.co.jp
- 国家：日本
- 产品数：6756
- 优势度：74
- 公司名称：NACALAI
- 联系电话：--
- 电子邮件：info-tech@nacalai.co.jp
- 国家：日本
- 产品数：6046
- 优势度：75
