五味子丙素
- CAS号:61301-33-5
- 英文名:WUWEIZISU C
- 中文名:五味子丙素
- CBNumber:CB2327435
- 分子式:C22H24O6
- 分子量:384.42
- MOL File:61301-33-5.mol
- 熔点 :122-123℃
- 沸点 :549.2±50.0 °C(Predicted)
- 密度 :1.232
- 溶解度 :DMSO : 8.33 mg/mL (21.67 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- 形态 :powder
- 颜色 :White
- LogP :5.623 (est)
五味子丙素性质、用途与生产工艺
- 生物活性 Schisandrin C (Schizandrin-C) 是从五味子中分离得到的一种植物化学木脂素 (lignan)。Schisandrin C 具有多种生物活性，包括抗癌、抗炎和抗氧化作用。Schisandrin C 可用于癌症、阿尔茨海默病、肝病的研究。Schisandrin C 诱导细胞凋亡 (apoptosis)。
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体外研究
Schisandrin C (25-100 μM; 48 hours) down-regulates expression levels of Bcl-2, Bcl-xL and a concomitant degradation of poly(ADP-ribose) polymerase (PARP). It also activates caspase-3 and -9 in U937 cells.Schisandrin C (25-100 μM; 48 hours) induces apoptosis in a dose-dependent manner. And the fragmentation of genomic DNA is also increased in U937 cells.Schisandrin C (25-100 μM; 72 hours) induces G1 arrest, it down-regulates cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, and also exhibits inhibition of pRB, and up-regulation of the Cdk inhibitor p21(WAF1/CIP1).
Western Blot Analysis
Cell Line: U937 cells Concentration: 25 μM,50 μM,100 μM Incubation Time: 48 hours Result: Decreased the expression of apoptosis related proteins. Apoptosis Analysis
Cell Line: U937 cells Concentration: 25 μM,50 μM,100 μM Incubation Time: 48 hours Result: Induced cell apoptosis. Cell Cycle Analysis
Cell Line: U937 cells Concentration: 25 μM,50 μM,100 μM Incubation Time: 48 hours Result: Induced growth inhibition and G1 arrest of U937 cells. -
体内研究
Schisandrin C (lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days) reduces Aβ1-42-induced memory deficits in the Y-maze test. Neurons in the hippocampus of SCH-C (15 μg/kg)-treated group returned to normal level, and and SCH-C group (150 μg/kg) has slight neuroprotective effects Aβ1-42-induced group. SCH-C (15 μg/kg) recoveres the activities of SOD and GSHPx and the ratios of GSH, decreases the levels of ChEtotal in the brain of the Aβ1–42-induced amnesic mice simultaneously.
Animal Model: Aβ1-42-induced Alzheimer’s disease mice Dosage: 15-150 μg/kg Administration: Lateral ventricle injection (i.c.v.); 15-150 μg/kg; 5 days Result: Exhibited potent neuroprotective effects linking to anti-ChEtotal activities and anti-oxidative mechanisms in Aβ1-42-induced amnestic mice. - 化学性质 无色晶体，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于五味子。
- 用途 五味子丙素具有拮抗 、抗癌、抗溃疡、保肝的作用。
- 公司名称：NACALAI
- 联系电话：--
- 电子邮件：info-tech@nacalai.co.jp
- 国家：日本
- 产品数：6046
- 优势度：75
