ChemicalBook CAS数据库列表 CTLA-4 - INHIBITOR
CTLA-4 - INHIBITOR
- CAS号:635324-72-0
- 英文名:2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
- 中文名:CTLA-4 - INHIBITOR
- CBNumber:CB23048865
- 分子式:C21H13F4N5O
- 分子量:427.35
- MOL File:635324-72-0.mol
CTLA-4 - INHIBITOR化学性质
- 沸点 :599.5±60.0 °C(Predicted)
- 密度 :1.54±0.1 g/cm3(Predicted)
- 储存条件 :Sealed in dry,Room Temperature
- 酸度系数(pKa) :5.76±0.20(Predicted)
- 形态 :Solid
- 颜色 :Off-white to light yellow
CTLA-4 - INHIBITOR性质、用途与生产工艺
- 生物活性 MDK 24720 (CTLA-4 inhibitor, copmound 6b) 是一种 Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4, CD152) 的抑制剂，对B7.1–CD28的抑制作用的IC50值为50 nM。
-
靶点
Target Value CD152
()B7.1–CD28
(Cell-free assay)50 nM -
体外研究
Bivalent CTLA4 homodimers bridge bivalent B7.1 homodimers to form an unusually stable signaling complex. Blocking B7/CD28 interactions with monoclonal antibodies or soluble receptors results in immunosuppression and enhanced allograft survival, while B7/CTLA-4 blockade results in enhanced antitumor immune responses. The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells. Consequently, agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases.
CTLA-4 - INHIBITOR上下游产品信息
上游原料
下游产品
CTLA-4 - INHIBITOR 试剂级价格
- 更新日期：2025/02/08
- 产品编号：HY-102090
- 产品名称：B7/CD28 interaction inhibitor 1
- CAS编号：635324-72-0
- 包装：1 mg
- 价格：940元
- 更新日期：2025/02/08
- 产品编号：HY-102090
- 产品名称：CTLA-4 - INHIBITOR B7/CD28 interaction inhibitor 1
- CAS编号：635324-72-0
- 包装：5mg
- 价格：2338元
CTLA-4 - INHIBITOR生产厂家
- 公司名称：A.J Chemicals
- 联系电话：--
- 电子邮件：sales@ajchem.in
- 国家：印度
- 产品数：6100
- 优势度：58
