CTLA-4 - INHIBITOR
中文名称:CTLA-4 - INHIBITOR
英文名称:2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
CAS号:635324-72-0
分子式:C21H13F4N5O
分子量:427.35
EINECS号:
Mol文件:635324-72-0.mol
CTLA-4 - INHIBITOR 性质
沸点 | 599.5±60.0 °C(Predicted) |
---|---|
密度 | 1.54±0.1 g/cm3(Predicted) |
储存条件 | Sealed in dry,Room Temperature |
酸度系数(pKa) | 5.76±0.20(Predicted) |
CTLA-4 - INHIBITOR 用途与合成方法
MDK 24720 (CTLA-4 inhibitor, copmound 6b) 是一种 Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4, CD152) 的抑制剂,对B7.1–CD28的抑制作用的IC50值为50 nM。
Target | Value |
CD152
() | |
B7.1–CD28
(Cell-free assay) | 50 nM |
Bivalent CTLA4 homodimers bridge bivalent B7.1 homodimers to form an unusually stable signaling complex. Blocking B7/CD28 interactions with monoclonal antibodies or soluble receptors results in immunosuppression and enhanced allograft survival, while B7/CTLA-4 blockade results in enhanced antitumor immune responses. The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells. Consequently, agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases.
CTLA-4 - INHIBITOR 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-04-30 | HY-102090 | 1 mg | 940 | ||
2024-04-30 | HY-102090 | CTLA-4 - INHIBITOR | 635324-72-0 | 10mM * 1mLin DMSO | 2590 |
CTLA-4 - INHIBITOR供应商 更多
武汉丰泰威远科技有限公司
联系电话:027-87465837 19945049750
产品介绍:
英文名称:2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3,4-d]pyridin-3(6H)-one
CAS:635324-72-0
纯度:97%
包装信息:1g,5g,25g,500g,1kg
备注:试剂级
上海创赛科技有限公司
联系电话:400-6087598 15021221957
产品介绍:
英文名称:CTLA-4-inhibitor
CAS:635324-72-0
纯度:98%
包装信息:1mg;25mg;5mg
上海思言生物科技有限公司
联系电话:021-50908862,442785678,326799392 18721037013
产品介绍:
CAS:635324-72-0
纯度:98% HPLC
包装信息:25g,100g,500g,1kg,5kg,25kg
上海超岚化工科技中心
联系电话:QQ:65489617 15618227136
产品介绍:
英文名称:CTLA-4 - inhibitor
CAS:635324-72-0
纯度:98%
包装信息:5MG;10MG;50MG;100MG,1G,5G,100G
北京普西唐生物科技有限公司
联系电话:010-60605840 18892239720
产品介绍:
英文名称:MDK24720
CAS:635324-72-0
纯度:98%(HPLC)
包装信息:25mg;5mg;100mg