依普西隆

生物活性靶点体内研究依普西隆试剂级价格

依普西隆

CAS号:95847-70-4
英文名:Ipsapirone
中文名:依普西隆
CBNumber:CB2254702
分子式:C19H23N5O3S
分子量:401.48
MOL File:95847-70-4.mol

依普西隆化学性质

熔点 :137-138°
沸点 :629.8±65.0 °C(Predicted)
密度 :1.345±0.06 g/cm3(Predicted)
储存条件 :Store at RT
溶解度 :Soluble to 10 mM in DMSO
形态 :Powder
酸度系数(pKa) :7.69±0.10(Predicted)
颜色 :White to off-white

依普西隆性质、用途与生产工艺

生物活性 Ipsapirone (TVX Q 7821)，是具有抗焦虑活性的化合物，是 5-HT1A 受体的部分激动剂，也表现出 5-HT1A 受体的拮抗作用，并且只在高剂量时，对 5-HT2 和α1 肾上腺素能表现出抑制作用。
靶点

5-HT _1A Receptor

体内研究

Ipsapirone inhibits induced by 8-OH-DPAT and 5-methoxydimethyltryptamine (agonists of 5-HT1A receptors) behavioural effects (flat body posture and forepaw treading) in normal and reserpinized rats.
Ipsapirone (2.5-80 mg/kg), given alone to rats induces a slight flattening of body posture (~ 1 point at the highest dose) and a mild hind limb abduction observed at doses 2.5-80 mg/kg. Ipsapirone given alone at low doses (2.5-10 mg/kg i.p.) does not significantly change the body temperature in rats and mice, but decreased it in both those species at high doses (35 mg/kg i.p.) by ca. 2-2.5℃.

Animal Model:	Male Albino-Swiss mice (18-24 g) and male Wistar rats (160-200 g).
Dosage:	5 and 10 mg/kg.
Administration:	IP 30 min before 8-OH-DPAT and 5-MeODMT injections.
Result:	Behavioural responses (flat body posture, forepaw treading) to 8-OH-DPAT (5 mg/kg s.c.) in rats were antagonized by Ipsapirone (5 and 10 mg/kg i.p.).