CINANSERIN HYDROCHLORIDE
- CAS号:54-84-2
- 英文名:CINANSERIN HYDROCHLORIDE
- 中文名:CINANSERIN HYDROCHLORIDE
- CBNumber:CB2254025
- 分子式:C20H25ClN2OS
- 分子量:376.94
- MOL File:54-84-2.mol
- 密度 :1.22 g/cm3
- 储存条件 :Inert atmosphere,Store in freezer, under -20°C
- 溶解度 :DMSO : 125 mg/mL (331.62 mM; Need ultrasonic)
- 形态 :Powder
- 颜色 :Light yellow to yellow
- 水溶解性 :Soluble to 50 mM in water
- 海关编码 :2921490090
CINANSERIN HYDROCHLORIDE性质、用途与生产工艺
- 生物活性 Cinanserin hydrochloride (SQ 10643) 是一种有效，选择性和高度亲和力的 5-HT2 受体拮抗剂，Ki 为 41 nM。Cinanserin hydrochloride 对 5-HT2 的结合亲和力比对 5-HT1 受体 (Ki 为 3500 nM) 的结合亲和力高得多。Cinanserin hydrochloride 还是严重急性呼吸系统综合症冠状病毒的 3C 样蛋白酶 (3C-like proteinase) 的抑制剂，可大大减少体外的病毒复制。
-
靶点
5-HT 2 Receptor
41 nM (Ki)
3C-like proteinase
-
体外研究
Cinanserin/Cinanserin hydrochloride have binding affinity to SARS-CoV 3CL pro , HCoV-229E 3CL pro , with the K D values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CL pro and 18.2 μM/36.6 μM for human coronavirus 229E (HCoV-229E) 3CL pro .
The IC 50 values of Cinanserin and Cinanserin hydrochloride for inhibiting the catalytic activity of SARS-CoV 3CL pro are calculated as 4.92 μM and 5.05 μM, respectively, The corresponding IC 50 values for HCoV-229E 3CL pro are 4.68 μM and 5.68 μM. None of the compounds have inhibitory activity against HRV-14 3C pro at concentrations up to 200 μM. -
体内研究
Cinanserin (5 mg/kg; intravenous injection; for 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels. Leukocyte-endothelial interactions are significantly reduced by administration of Cinanserin.
Animal Model: Male Wistar rats (250 g) underwent thermal injury Dosage: 5 mg/kg Administration: Intravenous injection; for 2 hours Result: Significantly reduced systemic burn edema to shamburn levels..
- 更新日期：2025/02/08
- 产品编号：HY-100943
- 产品名称：CINANSERIN HYDROCHLORIDE Cinanserin hydrochloride
- CAS编号：54-84-2
- 包装：1 mg
- 价格：673元
- 更新日期：2025/02/08
- 产品编号：HY-100943
- 产品名称：CINANSERIN HYDROCHLORIDE Cinanserin hydrochloride
- CAS编号：54-84-2
- 包装：10mM * 1mLin DMSO
- 价格：1321元
- 公司名称：TOCRIS-US
- 联系电话：--
- 电子邮件：customerservice@tocris.co.uk
- 国家：英国
- 产品数：5726
- 优势度：77
- 公司名称：APOLLO-NMR
- 联系电话：--
- 电子邮件：sales@apolloscientific.co.uk
- 国家：英国
- 产品数：6084
- 优势度：88
