2'-去氧-2'-氟-2'-C-甲基胞苷
- CAS号:817204-33-4
- 英文名:2'-deoxy-2'-fluoro-2'-C-methylcytidine
- 中文名:2'-去氧-2'-氟-2'-C-甲基胞苷
- CBNumber:CB22525888
- 分子式:C10H14FN3O4
- 分子量:259.23
- MOL File:817204-33-4.mol
- 熔点 :216-218℃
- 沸点 :482.4±55.0 °C(Predicted)
- 密度 :1.67
- 储存条件 :Hygroscopic, -20°C Freezer, Under inert atmosphere
- 溶解度 :Methanol (Slightly), Water (Slightly)
- 酸度系数(pKa) :12.86±0.70(Predicted)
- 形态 :Solid
- 颜色 :White to Light Brown
- 稳定性 :Hygroscopic
2'-去氧-2'-氟-2'-C-甲基胞苷性质、用途与生产工艺
- 生物活性 PSI-6130 是高效的，有选择性的 HCV NS5B polymerase 抑制剂，能够抑制HCV复制，IC50 值为 0.6 μM。
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靶点
IC50: 0.6 μM (HCV replication)
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体外研究
PSI-6130 exhibits potent and specific inhibitory activity against HCV RNA replication mediated by the NS5B polymerase. Both PSI-6130 inhibit HCV GT-1b (Con1 strain) and GT-1a (H77 strain) subgenomic RNA replication, with mean EC 50 values of 0.51 and 0.30 μM, respectively. PSI-6130 inhibits 40% human serum with EC 50 of 0.51 μM. PSI-6130 inhibits HCV replication with a mean IC 50 of 0.6 μM, PSI-6130-TP inhibits HCV replicase with a mean IC 50 of 0.34 μM. PSI-6130-TP inhibits recombinant HCV Con1 NS5B on a heteropolymeric RNA template derived from the 3′-end of the negative strand of the HCV genome with an IC 50 of 0.13 μM and K i of 0.023 μM.
- 更新日期：2024/11/08
- 产品编号：HY-10165
- 产品名称：2'-去氧-2'-氟-2'-C-甲基胞苷 PSI-6130
- CAS编号：817204-33-4
- 包装：2mg
- 价格：887元
- 更新日期：2024/11/08
- 产品编号：HY-10165
- 产品名称：2'-去氧-2'-氟-2'-C-甲基胞苷 PSI-6130
- CAS编号：817204-33-4
- 包装：10mM * 1mLin DMSO
- 价格：1265元
- 公司名称：Carbosynth
- 联系电话：--
- 电子邮件：sales@carbosynth.com
- 国家：英国
- 产品数：6005
- 优势度：58
