ChemicalBook CAS数据库列表 (D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P
(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P
- CAS号:91224-37-2
- 英文名:D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE
- 中文名:(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P
- CBNumber:CB2230566
- 分子式:C75H108N20O13
- 分子量:1497.79
- MOL File:91224-37-2.mol
(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P化学性质
- 密度 :1.43±0.1 g/cm3(Predicted)
- 储存条件 :−20°C
- 形态 :Powder
- 酸度系数(pKa) :13.31±0.20(Predicted)
- 颜色 :White to off-white
- 水溶解性 :Soluble to 1 mg/ml in water
安全信息
- WGK Germany :3
(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P性质、用途与生产工艺
- 生物活性 Spantide I 是substance P 的类似物，是选择性的神经激肽-1 受体 (NK1 receptor) 的拮抗剂，其对NK1 和 NK2 受体的 Ki 值分别为 230 nM 和 8150 nM。Spantide I 可减少感染角膜的1型细胞因子和增强2型细胞因子 IL-10，从而显著减少角膜穿孔。
-
靶点
NK1
230 nM (Ki)
NK2
8150 nM (Ki)
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体内研究
Spantide I (50 and 100 nM perfused through the cerebral ventricles) causes a complete respiratory arrest in all of the examined animals.
Spantide I (36 μg/mouse, ip daily) significantly decreases the number of perforated corneas, bacterial counts, and PMNs. Spantide I also downregulates the mRNA levels for type I cytokines (e.g., IFN-γ) as well as MIP-2, IL-6, TNF-α, and IL-1β.
Animal Model: Female, 8-week-old C57BL/6 (B6) and BALB/c mice. Dosage: 36 μg/mouse. Administration: IP on days -1 and 0 (day of infection) and daily through 5 days pi (post infection). Result: At 3 and 5 days pi, compound-treated mice had significantly less severe ocular disease than did the PBS-treated mice.
Contained significantly fewer PMNs than the corneas of PBS-treated mice at 3 and 5 days pi.
Significantly reduced levels of corneal TNF-α mRNA at 3 and 5 days pi.
Significantly reduced the level of IL-18 mRNA at 1 day pi.
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(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P 试剂级价格
- 更新日期：2024/11/08
- 产品编号：HY-P1194
- 产品名称：(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P Spantide I
- CAS编号：91224-37-2
- 包装：1 mg
- 价格：550元
- 更新日期：2024/11/08
- 产品编号：HY-P1194
- 产品名称：(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P Spantide I
- CAS编号：91224-37-2
- 包装：5 mg
- 价格：1650元
(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P生产厂家
- 公司名称：SIGMA
- 联系电话：--
- 电子邮件：
- 国家：瑞士
- 产品数：6896
- 优势度：91
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