(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P
(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P
英文名称:D-ARG-PRO-LYS-PRO-GLN-GLN-D-TRP-PHE-D-TRP-LEU-LEU-NH2 HYDROCHLORIDE
CAS号:91224-37-2
分子式:C75H108N20O13
分子量:1497.79
EINECS号:
Mol文件:91224-37-2.mol
(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P 性质
密度 | 1.43±0.1 g/cm3(Predicted) |
---|---|
储存条件 | −20°C |
形态 | 粉末 |
酸度系数(pKa) | 13.31±0.20(Predicted) |
颜色 | 白色至米白色 |
水溶解性 | Soluble to 1 mg/ml in water |
(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P 用途与合成方法
Spantide I 是substance P 的类似物,是选择性的神经激肽-1 受体 (NK1 receptor) 的拮抗剂,其对NK1 和 NK2 受体的 Ki 值分别为 230 nM 和 8150 nM。Spantide I 可减少感染角膜的1型细胞因子和增强2型细胞因子 IL-10,从而显著减少角膜穿孔。
NK1 230 nM (Ki) |
NK2 8150 nM (Ki) |
Spantide I (50 and 100 nM perfused through the cerebral ventricles) causes a complete respiratory arrest in all of the examined animals.
Spantide I (36 μg/mouse, ip daily) significantly decreases the number of perforated corneas, bacterial counts, and PMNs. Spantide I also downregulates the mRNA levels for type I cytokines (e.g., IFN-γ) as well as MIP-2, IL-6, TNF-α, and IL-1β.
Animal Model: | Female, 8-week-old C57BL/6 (B6) and BALB/c mice. |
Dosage: | 36 μg/mouse. |
Administration: | IP on days -1 and 0 (day of infection) and daily through 5 days pi (post infection). |
Result: |
At 3 and 5 days pi, compound-treated mice had significantly less severe ocular disease than did the PBS-treated mice.
Contained significantly fewer PMNs than the corneas of PBS-treated mice at 3 and 5 days pi. Significantly reduced levels of corneal TNF-α mRNA at 3 and 5 days pi. Significantly reduced the level of IL-18 mRNA at 1 day pi. |
(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P 价格(试剂级)
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024-11-08 | HY-P1194 | (D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P | 91224-37-2 | 1 mg | 550 |
2024-11-08 | HY-P1194 | (D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P | 91224-37-2 | 5 mg | 1650 |
(D-ARG1,D-TRP7·9,LEU11)-SUBSTANCE P供应商 更多
武汉易泰科技有限公司上海分公司
联系电话:821-50328103-801 18930552037
产品介绍:
英文名称:Spantide I
CAS:91224-37-2
纯度:99% HPLC
包装信息:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
吉尔生化(上海)有限公司
联系电话:21-61263452 13641803416
产品介绍:
英文名称:Substance P, [D-Arg1,D-Trp7&9,Leu11]-
CAS:91224-37-2
纯度:95% HPLC,98% HPLC
包装信息:10mg, 25mg, 50mg, 100mg, 500mg, 1g,10g
合肥赛曼诺生物科技有限公司
联系电话:0551-65326643 18156095617
产品介绍:
英文名称:(D-Arg1,D-Trp7·9,Leu11)-Substance P
CAS:91224-37-2
纯度:98% HPLC
包装信息:5Mg;10Mg;1g
南京莱昂生物科技有限公司
联系电话: 17705183659
产品介绍:
英文名称:Substance P-[D-Arg1,D-Trp7,9,Leu11]
CAS:91224-37-2
纯度:98% HPLC
包装信息:5mg;1G;10G;100G;1KG
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[D-Arg1,D-Trp7,9,Leu11]-Substance P/91224-37-2/NK1受体拮抗剂多肽
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